Residue number
Subdomain
Segment
Sequence-based (CAN)
Structure-based (ArrestinDb)
[Olive baboon] Beta-arrestin-2
[Green monkey] Beta-arrestin-2
[Horse] Beta-arrestin-2
[Rainbow trout] Arrestin red cell isoform 1
[Rainbow trout] Arrestin red cell isoform 2
[Rainbow trout] Arrestin red cell isoform 3
[Bovine] Beta-arrestin-2
[Human] Beta-arrestin-2
[Mouse] Beta-arrestin-2
[Sumatran orangutan] Beta-arrestin-2
[Rat] Beta-arrestin-2
[Rhesus macaque] Beta-arrestin-2
[Little brown bat] Beta-arrestin-2
[Northern white-cheeked gibbon] Beta-arrestin-2
[Rabbit] Beta-arrestin-2
[Three-spined stickleback] Arrestin, beta 2a
[Small-eared galago] Beta-arrestin-2
[Chimpanzee] Beta-arrestin-2
[Nile tilapia] Arrestin red cell
[European domestic ferret] Beta-arrestin-2
[Sheep] Beta-arrestin-2
Subdomain
Segment
Sequence-based (CAN)
Structure-based (ArrestinDb)
Seq consensus
Prop consensus
Length
RESIDUE PROPERTIES & LENGTH
Hydrophobic HY any
Hydrophobic HY 4-5
Hydrophobic aliphatic HA any
Hydrophobic aliphatic HA 1-2
Hydrophobic aliphatic HA 2-3
Hydrophobic aliphatic HA 3
Hydrophobic aliphatic HA 3-4
Hydrophobic aliphatic [M] M 4
Hydrophob al / α-H prop - very high [A] A 1
Hydrophobic aliphatic [I] I
Hydrophobic aliphatic [L] L
Hydrophobic aliphatic [V] V
Hydrophobic aromatic HR any
Hydrophobic aromatic HR 4-5
Hydrophobic aromatic HR 5
Hydrophobic aromatic HR 5-6
Hydrophobic aromatic [W] W 6
Hydropob ar / H-bonding [Y] Y
Hydrophobic aromatic [F] F
Hydrogen bonding (polar) Hb any
Hydrogen bonding Hb 2
Hydrogen bonding Hb 3
Hydrogen bonding [N] N
Hydrogen bonding [Q] Q
Hydrogen bonding [S] S
Hydrogen bonding [T] T
Hydrogen bonding uncharged Hu 2-3
Hydrogen bonding uncharged Hu 3-4
Hydrogen bond acceptor Ha 2-3
Hydrogen bond acceptor Ha 3
Hydrogen bond acceptor Ha 3-4
Hydrogen bond acceptor Ha 4
Hydrogen bond donor Hd 4
Hydrogen bond donor Hd 4-5
Hydrogen bond donor Hd 5-6
Hydrogen bond donor Hd 6
Charged +- any
Charged +- 3-4
Charged +- 4-5
Charged positive + any
Charged pos / H bond / Hphob ar [H] H 4
Charged positive + 4-5
Charged positive [K] K 5
Charged positive + 5-6
Charged positive [R] R 6
Charged negative - any
Charged negative [D] D 3
Charged negative [E] E 4
Small Sm any
Small Sm 0-1
Small Sm 1-2
α-Helix propensity - high αH Hig
α-Helix propensity - low αH Min
α-Helix flexibility [G] G 0
α-Helix kink [P] P 2
Disulfide-forming (S-S) [C] C 2
Gap (no amino acid) -
RESIDUE Z-SCALES
Z1 (Lipophilicity)
Z2 (Steric properties)
Z3 (Electronic properties)
Z4 (PC1 several properties)
Z5 (PC2 several properties)
Subdomain
Segment
Sequence-based (CAN)
Structure-based (ArrestinDb)
 
                                                                                     
N
ns1
-
.8
N
ns1
-
.9
N
ns1
-
.10
N
ns1
-
.11
N
ns1
-
.12
N
ns1
-
.13
N
ns1
-
.14
N
ns1
-
.15
  N
S1
-
.1
N
S1
-
.2
N
S1
-
.3
N
S1
-
.4
N
S1
-
.5
  N
s1s2
-
.1
N
s1s2
-
.2
N
s1s2
-
.3
N
s1s2
-
.4
N
s1s2
-
.5
  N
S2
-
.1
N
S2
-
.2
N
S2
-
.3
N
S2
-
.4
N
S2
-
.5
  N
s2s3
-
.1
N
s2s3
-
.2
N
s2s3
-
.3
  N
S3
-
.1
N
S3
-
.2
N
S3
-
.3
N
S3
-
.4
  N
s3s4
-
.1
N
s3s4
-
.2
N
s3s4
-
.3
N
s3s4
-
.4
N
s3s4
-
.5
N
s3s4
-
.6
N
s3s4
-
.7
  N
S4
-
.1
N
S4
-
.2
N
S4
-
.3
N
S4
-
.4
N
S4
-
.5
N
S4
-
.6
N
S4
-
.7
  N
s4s5
-
.1
N
s4s5
-
.2
N
s4s5
-
.3
N
s4s5
-
.4
N
s4s5
-
.5
N
s4s5
-
.6
N
s4s5
-
.7
N
s4s5
-
.8
  N
S5
-
.1
N
S5
-
.2
N
S5
-
.3
N
S5
-
.4
N
S5
-
.5
N
S5
-
.6
N
S5
-
.7
N
S5
-
.8
N
S5
-
.9
N
S5
-
.10
N
S5
-
.11
N
S5
-
.12
  N
s5s6
-
.1
N
s5s6
-
.2
N
s5s6
-
.3
N
s5s6
-
.4
N
s5s6
-
.5
N
s5s6
-
.6
N
s5s6
-
.7
N
s5s6
-
.8
N
s5s6
-
.9
N
s5s6
-
.10
N
s5s6
-
.11
  N
S6
-
.1
N
S6
-
.2
N
S6
-
.3
N
S6
-
.4
N
S6
-
.5
N
S6
-
.6
N
S6
-
.7
N
S6
-
.8
N
S6
-
.9
N
S6
-
.10
N
S6
-
.11
N
S6
-
.12
N
S6
-
.13
  N
s6h1
-
.1
N
s6h1
-
.2
N
s6h1
-
.3
N
s6h1
-
.4
N
s6h1
-
.6
N
s6h1
-
.7
N
s6h1
-
.8
N
s6h1
-
.9
N
s6h1
-
.10
N
s6h1
-
.11
N
s6h1
-
.12
  N
H1
-
.1
N
H1
-
.2
N
H1
-
.3
N
H1
-
.4
N
H1
-
.5
N
H1
-
.6
N
H1
-
.7
N
H1
-
.8
N
H1
-
.9
N
H1
-
.10
  N
h1s7
-
.1
N
h1s7
-
.2
N
h1s7
-
.3
  N
S7
-
.1
N
S7
-
.2
N
S7
-
.3
N
S7
-
.4
N
S7
-
.5
N
S7
-
.6
  N
s7s8
-
.1
N
s7s8
-
.2
N
s7s8
-
.3
N
s7s8
-
.4
N
s7s8
-
.5
N
s7s8
-
.6
N
s7s8
-
.7
N
s7s8
-
.8
N
s7s8
-
.9
  N
S8
-
.1
N
S8
-
.2
N
S8
-
.3
  N
s8s9
-
.1
N
s8s9
-
.2
N
s8s9
-
.3
N
s8s9
-
.4
N
s8s9
-
.5
N
s8s9
-
.6
N
s8s9
-
.7
N
s8s9
-
.8
N
s8s9
-
.9
N
s8s9
-
.10
  N
S9
-
.1
N
S9
-
.2
N
S9
-
.3
N
S9
-
.4
N
S9
-
.5
N
S9
-
.6
N
S9
-
.7
N
S9
-
.8
N
S9
-
.9
N
S9
-
.10
N
S9
-
.11
N
S9
-
.12
  N
s9s10
-
.1
N
s9s10
-
.2
N
s9s10
-
.3
N
s9s10
-
.7
N
s9s10
-
.8
N
s9s10
-
.9
N
s9s10
-
.10
N
s9s10
-
.11
N
s9s10
-
.12
N
s9s10
-
.13
N
s9s10
-
.14
  N
S10
-
.1
N
S10
-
.2
N
S10
-
.3
N
S10
-
.4
N
S10
-
.5
N
S10
-
.6
N
S10
-
.7
N
S10
-
.8
N
S10
-
.9
N
S10
-
.10
N
S10
-
.11
  C
s10s11
-
.1
C
s10s11
-
.2
C
s10s11
-
.3
C
s10s11
-
.4
C
s10s11
-
.5
C
s10s11
-
.6
C
s10s11
-
.7
C
s10s11
-
.8
C
s10s11
-
.9
C
s10s11
-
.10
  C
S11
-
.1
C
S11
-
.2
C
S11
-
.3
C
S11
-
.4
C
S11
-
.5
C
S11
-
.6
  C
s11s12
-
.1
C
s11s12
-
.2
C
s11s12
-
.3
C
s11s12
-
.4
C
s11s12
-
.5
C
s11s12
-
.6
C
s11s12
-
.7
C
s11s12
-
.8
  C
S12
-
.1
C
S12
-
.2
C
S12
-
.3
C
S12
-
.4
C
S12
-
.5
C
S12
-
.6
C
S12
-
.7
  C
s12s13
-
.1
C
s12s13
-
.2
C
s12s13
-
.3
  C
S13
-
.1
C
S13
-
.2
C
S13
-
.3
  C
s13s14
-
.1
C
s13s14
-
.2
C
s13s14
-
.3
C
s13s14
-
.4
  C
S14
-
.1
C
S14
-
.2
C
S14
-
.3
C
S14
-
.4
C
S14
-
.5
C
S14
-
.6
C
S14
-
.7
C
S14
-
.8
C
S14
-
.9
  C
s14s15
-
.1
C
s14s15
-
.2
C
s14s15
-
.3
C
s14s15
-
.4
C
s14s15
-
.5
  C
S15
-
.1
C
S15
-
.2
C
S15
-
.3
C
S15
-
.4
C
S15
-
.5
C
S15
-
.6
C
S15
-
.7
C
S15
-
.8
C
S15
-
.9
C
S15
-
.10
C
S15
-
.11
C
S15
-
.12
C
S15
-
.13
C
S15
-
.14
  C
s15s16
-
.1
C
s15s16
-
.2
C
s15s16
-
.3
C
s15s16
-
.4
C
s15s16
-
.5
  C
S16
-
.1
C
S16
-
.2
C
S16
-
.3
C
S16
-
.4
C
S16
-
.5
C
S16
-
.6
C
S16
-
.7
C
S16
-
.8
C
S16
-
.9
C
S16
-
.10
C
S16
-
.11
C
S16
-
.12
  C
s16s17
-
.1
C
s16s17
-
.2
C
s16s17
-
.3
C
s16s17
-
.4
C
s16s17
-
.5
C
s16s17
-
.6
C
s16s17
-
.7
  C
S17
-
.1
C
S17
-
.2
C
S17
-
.3
C
S17
-
.4
C
S17
-
.5
C
S17
-
.6
C
S17
-
.7
C
S17
-
.8
C
S17
-
.9
  C
s17s18
-
.1
C
s17s18
-
.2
C
s17s18
-
.3
C
s17s18
-
.4
C
s17s18
-
.5
C
s17s18
-
.6
C
s17s18
-
.7
C
s17s18
-
.8
C
s17s18
-
.9
C
s17s18
-
.10
C
s17s18
-
.11
C
s17s18
-
.12
C
s17s18
-
.13
C
s17s18
-
.14
C
s17s18
-
.15
C
s17s18
-
.16
C
s17s18
-
.17
C
s17s18
-
.18
C
s17s18
-
.19
C
s17s18
-
.20
C
s17s18
-
.21
C
s17s18
-
.22
C
s17s18
-
.23
C
s17s18
-
.24
C
s17s18
-
.25
C
s17s18
-
.26
C
s17s18
-
.27
C
s17s18
-
.28
C
s17s18
-
.29
C
s17s18
-
.30
C
s17s18
-
.31
C
s17s18
-
.32
C
s17s18
-
.33
C
s17s18
-
.34
C
s17s18
-
.35
C
s17s18
-
.36
C
s17s18
-
.37
C
s17s18
-
.38
C
s17s18
-
.39
C
s17s18
-
.40
C
s17s18
-
.41
C
s17s18
-
.42
  C
S18
-
.1
C
S18
-
.2
C
S18
-
.3
C
S18
-
.4
C
S18
-
.5
C
S18
-
.6
C
S18
-
.7
C
S18
-
.8
C
S18
-
.9
C
S18
-
.10
C
S18
-
.11
C
S18
-
.12
C
S18
-
.13
  C
s18s19
-
.1
C
s18s19
-
.2
C
s18s19
-
.3
C
s18s19
-
.4
C
s18s19
-
.5
C
s18s19
-
.6
C
s18s19
-
.7
C
s18s19
-
.8
C
s18s19
-
.9
C
s18s19
-
.10
C
s18s19
-
.11
  C
S19
-
.1
C
S19
-
.2
C
S19
-
.3
C
S19
-
.4
C
S19
-
.5
C
S19
-
.6
C
S19
-
.7
C
S19
-
.8
C
S19
-
.9
C
S19
-
.10
C
S19
-
.11
C
S19
-
.12
C
S19
-
.13
  C
s19s20
-
.1
C
s19s20
-
.2
C
s19s20
-
.3
C
s19s20
-
.4
C
s19s20
-
.5
C
s19s20
-
.6
C
s19s20
-
.7
C
s19s20
-
.8
C
s19s20
-
.9
C
s19s20
-
.10
C
s19s20
-
.11
C
s19s20
-
.12
C
s19s20
-
.13
C
s19s20
-
.14
C
s19s20
-
.15
C
s19s20
-
.16
C
s19s20
-
.17
C
s19s20
-
.18
C
s19s20
-
.19
C
s19s20
-
.20
C
s19s20
-
.21
C
s19s20
-
.22
C
s19s20
-
.23
C
s19s20
-
.24
C
s19s20
-
.25
C
s19s20
-
.26
C
s19s20
-
.27
C
s19s20
-
.28
C
s19s20
-
.29
C
s19s20
-
.30
C
s19s20
-
.31
C
s19s20
-
.32
C
s19s20
-
.33
C
s19s20
-
.34
C
s19s20
-
.35
C
s19s20
-
.36
C
s19s20
-
.37
C
s19s20
-
.38
C
s19s20
-
.39
C
s19s20
-
.40
C
s19s20
-
.41
C
s19s20
-
.42
C
s19s20
-
.43
C
s19s20
-
.44
C
s19s20
-
.45
C
s19s20
-
.46
C
s19s20
-
.47
C
s19s20
-
.48
C
s19s20
-
.49
C
s19s20
-
.50
C
s19s20
-
.51
  C
S20
-
.1
C
S20
-
.2
C
S20
-
.3
C
S20
-
.4
C
S20
-
.5
  C
s20c
-
.1
C
s20c
-
.2
C
s20c
-
.3
C
s20c
-
.4
C
s20c
-
.5
C
s20c
-
.6
C
s20c
-
.7
C
s20c
-
.8
C
s20c
-
.9
C
s20c
-
.10
C
s20c
-
.11
C
s20c
-
.12
C
s20c
-
.13
C
s20c
-
.14
C
s20c
-
.15
C
s20c
-
.16
C
s20c
-
.17
C
s20c
-
.18
C
s20c
-
.19
 
M
G
E
K
P
G
T
R
 
V
F
K
K
S
 
S
P
N
C
K
 
L
T
V
Y
L
 
G
K
R
 
D
F
V
D
 
H
L
D
K
V
D
P
 
V
D
G
V
V
L
V
 
D
P
D
Y
L
K
D
R
 
K
V
F
V
T
L
T
C
A
F
R
Y
 
G
R
E
D
L
D
V
L
G
L
S
 
F
R
K
D
L
F
I
A
T
Y
Q
A
F
 
P
P
V
P
N
P
P
R
P
A
T
 
R
L
Q
D
R
L
L
R
K
L
 
G
Q
H
 
A
H
P
F
F
F
 
T
I
P
Q
N
L
P
C
S
 
V
T
L
 
Q
P
G
P
E
D
T
G
K
A
 
C
G
V
D
F
E
I
R
A
F
C
A
 
K
S
L
E
E
K
S
H
K
R
N
 
S
V
R
L
V
I
R
K
V
Q
F
 
A
P
E
K
P
G
P
Q
P
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