PDB
23IW
Resolution
2.4 Å
Released
May 20, 2026
Receptor
CB1
Class
A
Species
Homo sapiens
Ligand
LZD503
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
LZD503 F170 2.57x57 TM2 aromatic (edge-to-face)
LZD503 S173 2.60x60 TM2 polar (hydrogen bond)
LZD503 F177 2.64x64 TM2 Van der Waals
LZD503 F177 2.64x64 TM2 hydrophobic
LZD503 H178 2.65x65 TM2 Van der Waals
LZD503 F189 3.25x25 TM3 Van der Waals
LZD503 F189 3.25x25 TM3 hydrophobic
LZD503 L193 3.29x29 TM3 hydrophobic
LZD503 L193 3.29x29 TM3 Van der Waals
LZD503 V196 3.32x32 TM3 hydrophobic
LZD503 V196 3.32x32 TM3 Van der Waals
LZD503 T197 3.33x33 TM3 Van der Waals
LZD503 F200 3.36x36 TM3 Van der Waals
LZD503 F200 3.36x36 TM3 aromatic (edge-to-face)
LZD503 F268 ECL2 hydrophobic
LZD503 F268 ECL2 Van der Waals
LZD503 I271 ECL2 Van der Waals
LZD503 Y275 5.39x39 TM5 hydrophobic
LZD503 Y275 5.39x39 TM5 Van der Waals
LZD503 L276 5.40x40 TM5 Van der Waals
LZD503 L276 5.40x40 TM5 hydrophobic
LZD503 W279 5.43x43 TM5 Van der Waals
LZD503 W279 5.43x43 TM5 aromatic (face-to-edge)
LZD503 M363 6.55x55 TM6 hydrophobic
LZD503 M363 6.55x55 TM6 Van der Waals
LZD503 F379 7.35x34 TM7 hydrophobic
LZD503 F379 7.35x34 TM7 Van der Waals

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ICL1 R S L R C ICL1ECL1 F H R K D ECL1ICL2 P L A Y K R I V ICL2ECL2 W N C E K L Q S V C S D I F P H I ECL2ICL3 T Q K S I I I H T S E D G K V Q V T R ICL3ECL3 K M ECL3N-term M K S I L D G L A D T T F R T I T T D L L Y V G S N D I Q Y E D I K G D M A S K L G Y F P Q K F P L T S F R G S P F Q E K M T A G D N P Q L V P A D Q V N I T E F Y N K S L S S F K E N E E N I Q C G E N F M D I E C F M V L N-termC-term S C E G T A Q P L D N S M G D S D C L H K H A N N A A S V H R A A E S C I K S T V K I A K V T M S V S T D T S A E A L C-term N P S Q Q L A I A V L S L T L G T F T V L E N L L V L C V I L H S R P S Y H F I G S L A V A D L L G S V I F V Y S F I D F H V S R N V F L F K L G G V T A S F T A S V G S L F L T A I D R Y I S I H R T R P K A V V A F C L M W T I A I V I A V L P L L G D E T Y L M F W I G V T S V L L L F I V Y A Y M Y I L W K A H S H A V R M I Q R G P D Q A R M D I R L A K T L V L I L V V L I I C W G P L L A I M V Y D V F G N K L I K T V F A F C S M L C L L N S T V N P I I Y A L R S K D F R S L R H A M F P
Helix box plot — Download: PNG | SVG L N E L V T F T G L T L S L V A I A L Q 1 G S L A V A D L L G S V I F V Y S F I D 2 L F L S G V S A T F S A T V G G L K F L 3 A V V A F C L M W T I A I V I A V L P L 4 Y A Y V I F L L L V S T V G I W F M L Y 5 V L I L V V L I I C W G P L L A I M V Y 6 I P N V T S N L L C L M S C F A F V T 7

GPCRdb(A)
GPCRdb(A)
CB1 receptor
TM2
2x57 2.57x57 F170
2x60 2.60x60 S173
2x64 2.64x64 F177
2x65 2.65x65 H178
TM3
3x25 3.25x25 F189
3x29 3.29x29 L193
3x32 3.32x32 V196
3x33 3.33x33 T197
3x36 3.36x36 F200
TM5
5x39 5.39x39 Y275
5x40 5.40x40 L276
5x43 5.43x43 W279
TM6
6x55 6.55x55 M363
TM7
7x34 7.35x34 F379