CB1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.4 Å

REFERENCE

PUBLICATION DATE

May 20, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

LZD503 - Agonist pubchem

PHYSIOLOGICAL LIGANDS

anandamide, 2-arachidonoylglycerol



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Hydrophobic ICL2 Y 224 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 Y 224 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 L 222 - G.S3 L 194 G.S3.01
Polar ICL2 L 222 - G.hns1 R 32 G.hns1.03
Polar H8 S 401 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 S 401 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 S 401 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM5 H 304 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 H 304 5x68 G.H5 I 344 G.H5.16
Polar TM5 Q 310 5x74 G.H5 D 337 G.H5.09
Hydrophobic TM5 Q 310 5x74 G.H5 D 337 G.H5.09
Van-der-waals TM5 Q 310 5x74 G.H5 D 337 G.H5.09
Polar ICL2 P 221 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 221 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 221 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 Y 224 - G.H5 D 350 G.H5.22
Hydrophobic TM5 H 304 5x68 G.H5 T 340 G.H5.12
Hydrophobic ICL2 A 223 - G.hns1 R 32 G.hns1.03
Hydrophobic H8 S 401 8x47 G.H5 F 354 G.H5.26
Hydrophobic TM3 I 218 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 218 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 345 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 221 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 221 - G.H5 I 344 G.H5.16
Hydrophobic ICL2 P 221 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 221 - G.H5 I 343 G.H5.15
Polar TM3 R 214 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 214 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 214 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 L 222 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 222 - G.H5 I 343 G.H5.15
Hydrophobic TM2 S 152 2x39 G.H5 C 351 G.H5.23
Aromatic TM6 R 340 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 340 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 340 6x32 G.H5 F 354 G.H5.26
Polar H8 K 402 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 K 402 8x48 G.H5 F 354 G.H5.26
Polar TM3 S 217 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 S 217 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 214 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 214 3x50 G.H5 L 353 G.H5.25
Polar TM2 S 152 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 S 152 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM6 M 337 6x29 G.H5 I 344 G.H5.16
Hydrophobic TM6 M 337 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 R 226 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 226 - G.hns1 R 32 G.hns1.03
Hydrophobic TM6 M 337 6x29 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 341 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 341 6x33 G.H5 F 354 G.H5.26
Ionic TM5 H 304 5x68 G.H5 D 341 G.H5.13
Polar TM5 H 304 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 H 304 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 H 304 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM6 L 341 6x33 G.H5 L 353 G.H5.25