Structure information

NTS1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6OSA

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

REFERENCE

10.1038/S41586-019-1337-6

PUBLICATION DATE

July 10, 2019

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
JMV449 E53 N-term Van der Waals
JMV449 E53 N-term polar (hydrogen bond with backbone)
JMV449 L54 N-term hydrophobic
JMV449 L54 N-term Van der Waals
JMV449 F127 2.65x64 TM2 Van der Waals
JMV449 F127 2.65x64 TM2 hydrophobic
JMV449 H131 ECL1 polar (hydrogen bond)
JMV449 H131 ECL1 polar (hydrogen bond with backbone)
JMV449 Y145 3.29x29 TM3 polar (hydrogen bond)
JMV449 Y145 3.29x29 TM3 polar (hydrogen bond)
JMV449 M207 4.64x65 TM4 Van der Waals
JMV449 V223 ECL2 Van der Waals
JMV449 V223 ECL2 hydrophobic
JMV449 T225 45.51x51 ECL2 Van der Waals
JMV449 R322 6.54x54 TM6 Van der Waals
JMV449 R323 6.55x55 TM6 Van der Waals
JMV449 F326 6.58x58 TM6 Van der Waals
JMV449 F326 6.58x58 TM6 hydrophobic
JMV449 D331 ECL3 polar (charge-assisted hydrogen bond)
JMV449 W334 ECL3 Van der Waals
JMV449 W334 ECL3 hydrophobic
JMV449 Y339 7.28x27 TM7 hydrophobic
JMV449 Y339 7.28x27 TM7 Van der Waals
JMV449 Y342 7.31x30 TM7 polar (hydrogen bond)
JMV449 Y342 7.31x30 TM7 Van der Waals
JMV449 H343 7.32x31 TM7 Van der Waals
JMV449 Y346 7.35x34 TM7 hydrophobic
JMV449 Y346 7.35x34 TM7 Van der Waals

Ligands

JMV449

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Residue Diagrams

T N G V T G V V F L A L Y V A T V L V K 1 G S L A L S D L L T L L L A M P V E L Y N 2 S A V N L A T A Y T C A D R L F Y Y G R 3 T K K F I S A I W L A S A L L A V P M 4 N L V S I V V M P F I F S M F T N V Q I V 5 R A V V I A F V V C W L P Y H V R R L M 6 I P N I T S S V Y F L A N T V M Y F Y 7
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ICL1 K S L Q ICL1ECL1 H H P W A F ECL1ICL2 P F K A K T L M ICL2ECL2 G E Q N R S A D G Q H A G G L V C T P T I ECL2ICL3 Q V C T V G G E H S T F S M A I E ICL3ECL3 S D E Q W ECL3N-term M R L N S S A P G T P G T P A A D P F Q R A Q A G L E E A L L A P G F G N A S G N A S E R V L A A P S S E L D V N T N-termC-term P V W R R R R K R P A F S R K A D S V S S N H T L S S N A T R E T L Y C-term D I Y S K V L V T A V Y L A L F V V G T V G N T V T A F T L A R K S L Q S T V H Y H L G S L A L S D L L T L L L A M P V E L Y N F I W V G D A G C R G Y Y F L R D A C T Y A T A L N V A S L S V E R Y L A I C H S R S R T K K F I S A I W L A S A L L A V P M L F T M H T A T V K V V I Q V N T F M S F I F P M V V I S V L N T I I A N K L T V M V R Q A A E Q G P G R V Q A L R H G V R V L R A V V I A F V V C W L P Y H V R R L M F C Y I T P F L Y D F Y H Y F Y M V T N A L F Y V S S T I N P I L Y N L V S A N F L A L C F R H I T L A C
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Residue Table


GPCRdb(A)
GPCRdb(A)
NTS1 receptor
TM2
2x64 2.65x64 F127
TM3
3x29 3.29x29 Y145
TM4
4x65 4.64x65 M207
ECL2
45x51 45.51x51 T225
TM6
6x54 6.54x54 R322
6x55 6.55x55 R323
6x58 6.58x58 F326
TM7
7x27 7.28x27 Y339
7x30 7.31x30 Y342
7x31 7.32x31 H343
7x34 7.35x34 Y346