Structure information

LH receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7FIH

SPECIES

Homo sapiens

RESOLUTION

3.200

PREFERRED CHAIN

R

REFERENCE

10.1038/S41586-021-03924-2

PUBLICATION DATE

Sept. 29, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
5-Amino-N-(1,1-dimethylethyl)-2-(methylthio)-4-[3-[[2-(4-morpholinyl)acetyl]amino]phenyl]thieno[2,3-d]pyrimidine-6-carboxamide F350 N-term hydrophobic
5-Amino-N-(1,1-dimethylethyl)-2-(methylthio)-4-[3-[[2-(4-morpholinyl)acetyl]amino]phenyl]thieno[2,3-d]pyrimidine-6-carboxamide F515 45.51x51 ECL2 hydrophobic
5-Amino-N-(1,1-dimethylethyl)-2-(methylthio)-4-[3-[[2-(4-morpholinyl)acetyl]amino]phenyl]thieno[2,3-d]pyrimidine-6-carboxamide P516 45.52x52 ECL2 Van der Waals
5-Amino-N-(1,1-dimethylethyl)-2-(methylthio)-4-[3-[[2-(4-morpholinyl)acetyl]amino]phenyl]thieno[2,3-d]pyrimidine-6-carboxamide P516 45.52x52 ECL2 polar (hydrogen bond with backbone)
5-Amino-N-(1,1-dimethylethyl)-2-(methylthio)-4-[3-[[2-(4-morpholinyl)acetyl]amino]phenyl]thieno[2,3-d]pyrimidine-6-carboxamide M517 ECL2 hydrophobic
5-Amino-N-(1,1-dimethylethyl)-2-(methylthio)-4-[3-[[2-(4-morpholinyl)acetyl]amino]phenyl]thieno[2,3-d]pyrimidine-6-carboxamide M517 ECL2 Van der Waals
5-Amino-N-(1,1-dimethylethyl)-2-(methylthio)-4-[3-[[2-(4-morpholinyl)acetyl]amino]phenyl]thieno[2,3-d]pyrimidine-6-carboxamide I528 5.40x40 TM5 Van der Waals
5-Amino-N-(1,1-dimethylethyl)-2-(methylthio)-4-[3-[[2-(4-morpholinyl)acetyl]amino]phenyl]thieno[2,3-d]pyrimidine-6-carboxamide A589 6.55x55 TM6 Van der Waals
5-Amino-N-(1,1-dimethylethyl)-2-(methylthio)-4-[3-[[2-(4-morpholinyl)acetyl]amino]phenyl]thieno[2,3-d]pyrimidine-6-carboxamide A589 6.55x55 TM6 hydrophobic
5-Amino-N-(1,1-dimethylethyl)-2-(methylthio)-4-[3-[[2-(4-morpholinyl)acetyl]amino]phenyl]thieno[2,3-d]pyrimidine-6-carboxamide A592 6.58x58 TM6 hydrophobic
5-Amino-N-(1,1-dimethylethyl)-2-(methylthio)-4-[3-[[2-(4-morpholinyl)acetyl]amino]phenyl]thieno[2,3-d]pyrimidine-6-carboxamide A592 6.58x58 TM6 Van der Waals
5-Amino-N-(1,1-dimethylethyl)-2-(methylthio)-4-[3-[[2-(4-morpholinyl)acetyl]amino]phenyl]thieno[2,3-d]pyrimidine-6-carboxamide K595 6.61x61 TM6 polar (charge-assisted hydrogen bond)
5-Amino-N-(1,1-dimethylethyl)-2-(methylthio)-4-[3-[[2-(4-morpholinyl)acetyl]amino]phenyl]thieno[2,3-d]pyrimidine-6-carboxamide P597 ECL3 Van der Waals
5-Amino-N-(1,1-dimethylethyl)-2-(methylthio)-4-[3-[[2-(4-morpholinyl)acetyl]amino]phenyl]thieno[2,3-d]pyrimidine-6-carboxamide P597 ECL3 hydrophobic
5-Amino-N-(1,1-dimethylethyl)-2-(methylthio)-4-[3-[[2-(4-morpholinyl)acetyl]amino]phenyl]thieno[2,3-d]pyrimidine-6-carboxamide I599 ECL3 Van der Waals
5-Amino-N-(1,1-dimethylethyl)-2-(methylthio)-4-[3-[[2-(4-morpholinyl)acetyl]amino]phenyl]thieno[2,3-d]pyrimidine-6-carboxamide V601 7.31x30 TM7 Van der Waals
5-Amino-N-(1,1-dimethylethyl)-2-(methylthio)-4-[3-[[2-(4-morpholinyl)acetyl]amino]phenyl]thieno[2,3-d]pyrimidine-6-carboxamide V601 7.31x30 TM7 hydrophobic
5-Amino-N-(1,1-dimethylethyl)-2-(methylthio)-4-[3-[[2-(4-morpholinyl)acetyl]amino]phenyl]thieno[2,3-d]pyrimidine-6-carboxamide S604 7.34x33 TM7 polar (hydrogen bond)
5-Amino-N-(1,1-dimethylethyl)-2-(methylthio)-4-[3-[[2-(4-morpholinyl)acetyl]amino]phenyl]thieno[2,3-d]pyrimidine-6-carboxamide Y612 7.42x41 TM7 Van der Waals

Ligands

5-Amino-N-(1,1-dimethylethyl)-2-(methylthio)-4-[3-[[2-(4-morpholinyl)acetyl]amino]phenyl]thieno[2,3-d]pyrimidine-6-carboxamide

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Residue Diagrams

M N G M I A L I N I L W I L V R L F D Y 1 C N L S F A D F C M G L Y L L L I A S V 2 V T L T Y V S L E S A F V T F F G A T S 3 A I L I M L G G W L F S S L I A M L P L 4 Y C A C I I F F A V V N L I L I T L I Y 5 A I L I F T D F T C M A P I S F F A I S 6 F P N A C S N I P Y F L V L L V K S N 7
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ICL1 R Y K L ICL1ECL1 K G Q Y Y N H A I D W Q T ECL1ICL2 A I H L D Q K L ICL2ECL2 V S N Y M K V S I C F P M D V E ECL2ICL3 N P E L M ICL3ECL3 V P L I ECL3N-term M K Q R F S A L Q L L K L L L L L Q P P L P R A L R E A L C P E P C N C V P D G A L R C P G P T A G L T R L S L A Y L P V K V I P S Q A F R G L N E V I K I E I S Q I D S L E R I E A N A F D N L L N L S E I L I Q N T K N L R Y I E P G A F I N L P R L K Y L S I C N T G I R K F P D V T K V F S S E S N F I L E I C D N L H I T T I P G N A F Q G M N N E S V T L K L Y G N G F E E V Q S H A F N G T T L T S L E L K E N V H L E K M H N G A F R G A T G P K T L D I S S T K L Q A L P S Y G L E S I Q R L I A T S S Y S L K K L P S R E T F V N L L E A T L T Y P S H C C A F R N L P T K E Q N F S H S I S E N F S K Q C E S T V R K V N N K T L Y S S M L A E S E L S G W D Y E Y G F C L P K T P R C A P E P D A F N P C E D I M G N-termC-term G C C K R R A E L Y R R K D F S A Y T S N C K N G F T G S N K P S Q S T L K L S T L H C Q G T A L L D K T R Y T E C C-term Y D F L R V L I W L I N I L A I M G N M T V L F V L L T S T V P R F L M C N L S F A D F C M G L Y L L L I A S V D S Q T G S G C S T A G F F T V F A S E L S V Y T L T V I T L E R W H T I T Y R L R H A I L I M L G G W L F S S L I A M L P L V G T T L S Q V Y I L T I L I L N V V A F F I I C A C Y I K I Y F A V R A T N K D T K I A K K M A I L I F T D F T C M A P I S F F A I S A A F K T V T N S K V L L V L F Y P I N S C A N P F L Y A I F T K T F F L F F Q R D L L S K
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Residue Table


GPCRdb(A)
GPCRdb(A)
LH receptor
ECL2
45x51 45.51x51 F515
45x52 45.52x52 P516
TM5
5x40 5.40x40 I528
TM6
6x55 6.55x55 A589
6x58 6.58x58 A592
6x61 6.61x61 K595
TM7
7x30 7.31x30 V601
7x33 7.34x33 S604
7x41 7.42x41 Y612