Structure information

5-HT5A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7X5H

SPECIES

Homo sapiens

RESOLUTION

3.100

PREFERRED CHAIN

R

REFERENCE

10.1038/S41421-022-00412-3

PUBLICATION DATE

Sept. 14, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
5-CT D121 3.32x32 TM3 polar (charge-assisted hydrogen bond)
5-CT V122 3.33x33 TM3 hydrophobic
5-CT V122 3.33x33 TM3 Van der Waals
5-CT C125 3.36x36 TM3 polar (hydrogen bond)
5-CT T126 3.37x37 TM3 Van der Waals
5-CT V194 45.52x52 ECL2 Van der Waals
5-CT S204 5.42x43 TM5 Van der Waals
5-CT T205 5.43x44 TM5 Van der Waals
5-CT A208 5.46x461 TM5 Van der Waals
5-CT F301 6.51x51 TM6 Van der Waals
5-CT F301 6.51x51 TM6 hydrophobic
5-CT F302 6.52x52 TM6 hydrophobic
5-CT F302 6.52x52 TM6 Van der Waals
5-CT E305 6.55x55 TM6 polar (charge-assisted hydrogen bond)

Ligands

5-CT

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Residue Diagrams

L N W A F T A A V L F G L L T L I L V G 1 A S M A V S D V L V A L A V M P L S L V H 2 A T V N W I S A T C C L V D C A I W L Q 3 S N V M I A L T W A L S A V I S L A P L 4 Y V F L V V C L P L Y F A G V T S F V A Y 5 G I L I G V F V L C W I P F F L T E L I 6 L P N F F S N S Y G L W L F I S K W I 7
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ICL1 R T F H ICL1ECL1 R R W Q L ECL1ICL2 H M E Y T ICL2ECL2 W G E T Y S E G S E E C Q V S R ECL2ICL3 V S P I S E A V E V K D S A K Q P Q M V F T V R H A T V T F Q P E G D ICL3ECL3 S C D I ECL3N-term M D L P V N L T S F S L S T P S P L E T N H S L G K D D L R P S S P L N-termC-term S R Q H C-term L S V F G V L I L T L L G F L V A A T F A W N L L V L A T I L R V R V P H N L V A S M A V S D V L V A A L V M P L S L V H E L S G G R R L C Q L W I A C D V L C C T A S I W N V T A I A L D R Y W S I T R L R T R K C V S N V M I A L T W A L S A V I S L A P L L F G E P S Y A V F S T V G A F Y L P L C V V L F V Y W K I Y K A A K F R V G S R K T N S T W R E Q K E Q R A A L M V G I L I G V F V L C W I P F F L T E L I S P L C P A I W K S I F L W L G Y S N S F F N P L I Y T A F N K N F K N Y N S A F F
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT5A receptor
TM3
3x32 3.32x32 D121
3x33 3.33x33 V122
3x36 3.36x36 C125
3x37 3.37x37 T126
ECL2
45x52 45.52x52 V194
TM5
5x43 5.42x43 S204
5x44 5.43x44 T205
5x461 5.46x461 A208
TM6
6x51 6.51x51 F301
6x52 6.52x52 F302
6x55 6.55x55 E305