5-HT5A receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.1 Å

REFERENCE

PUBLICATION DATE

Sept. 14, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

5-CT - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

5-hydroxytryptamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM5 R 230 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 230 5x68 G.H5 I 344 G.H5.16
Ionic TM4 R 154 4x38 G.H5 D 350 G.H5.22
Polar TM4 R 154 4x38 G.H5 D 350 G.H5.22
Hydrophobic ICL2 H 146 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 H 146 - G.H5 I 344 G.H5.16
Hydrophobic ICL2 M 147 - G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 M 147 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 H 146 - G.H5 T 340 G.H5.12
Hydrophobic TM3 I 143 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 I 143 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM5 I 223 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 223 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM6 M 286 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM5 A 227 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 H 146 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 H 146 - G.H5 I 343 G.H5.15
Ionic TM4 R 152 4x36 G.HN E 28 G.HN.52
Polar TM4 R 152 4x36 G.HN E 28 G.HN.52
Van-der-waals TM4 R 152 4x36 G.HN E 28 G.HN.52
Hydrophobic TM6 R 282 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM3 I 143 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 I 143 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 143 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 143 3x54 G.H5 L 348 G.H5.20
Polar TM6 A 283 6x33 G.H5 L 353 G.H5.25
Polar TM3 R 139 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 139 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 139 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 V 287 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM5 R 230 5x68 G.H5 L 348 G.H5.20
Hydrophobic ICL2 M 147 - G.S3 L 194 G.S3.01
Aromatic TM6 K 279 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 279 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 279 6x29 G.H5 F 354 G.H5.26
Ionic TM5 R 230 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 230 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 230 5x68 G.H5 D 341 G.H5.13
Van-der-waals ICL2 H 146 - G.H5 N 347 G.H5.19
Hydrophobic TM5 I 223 5x61 G.H5 L 348 G.H5.20
Polar TM3 S 142 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 S 142 3x53 G.H5 N 347 G.H5.19