Structure information

CT receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

8F0J

SPECIES

Homo sapiens

RESOLUTION

2.000

PREFERRED CHAIN

R

REFERENCE

10.1038/S41589-023-01393-4

PUBLICATION DATE

Aug. 2, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Pramlintide analogue San45 L40 N-term hydrophobic
Pramlintide analogue San45 W79 N-term aromatic (face-to-edge)
Pramlintide analogue San45 F99 N-term hydrophobic
Pramlintide analogue San45 P100 N-term hydrophobic
Pramlintide analogue San45 D101 N-term polar (charge-assisted hydrogen bond)
Pramlintide analogue San45 F102 N-term Van der Waals
Pramlintide analogue San45 F102 N-term hydrophobic
Pramlintide analogue San45 H121 N-term Van der Waals
Pramlintide analogue San45 E123 N-term Van der Waals
Pramlintide analogue San45 N124 N-term polar (hydrogen bond)
Pramlintide analogue San45 R126 N-term polar (charge-assisted hydrogen bond)
Pramlintide analogue San45 W128 N-term Van der Waals
Pramlintide analogue San45 W128 N-term polar (hydrogen bond)
Pramlintide analogue San45 S129 N-term polar (hydrogen bond with backbone)
Pramlintide analogue San45 S129 N-term Van der Waals
Pramlintide analogue San45 Y131 N-term Van der Waals
Pramlintide analogue San45 Y131 N-term hydrophobic
Pramlintide analogue San45 A136 N-term hydrophobic
Pramlintide analogue San45 F137 N-term hydrophobic
Pramlintide analogue San45 F137 N-term Van der Waals
Pramlintide analogue San45 L142 1.33x33 TM1 hydrophobic
Pramlintide analogue San45 L142 1.33x33 TM1 Van der Waals
Pramlintide analogue San45 A145 1.36x36 TM1 hydrophobic
Pramlintide analogue San45 A145 1.36x36 TM1 Van der Waals
Pramlintide analogue San45 Y146 1.37x37 TM1 Van der Waals
Pramlintide analogue San45 Y146 1.37x37 TM1 hydrophobic
Pramlintide analogue San45 L148 1.39x39 TM1 hydrophobic
Pramlintide analogue San45 L148 1.39x39 TM1 Van der Waals
Pramlintide analogue San45 Y149 1.40x40 TM1 hydrophobic
Pramlintide analogue San45 Y149 1.40x40 TM1 Van der Waals
Pramlintide analogue San45 Y150 1.41x41 TM1 Van der Waals
Pramlintide analogue San45 I153 1.44x44 TM1 Van der Waals
Pramlintide analogue San45 I153 1.44x44 TM1 hydrophobic
Pramlintide analogue San45 H156 1.47x47 TM1 polar (hydrogen bond)
Pramlintide analogue San45 S157 1.48x48 TM1 Van der Waals
Pramlintide analogue San45 I160 1.51x51 TM1 hydrophobic
Pramlintide analogue San45 F161 1.52x52 TM1 Van der Waals
Pramlintide analogue San45 F161 1.52x52 TM1 hydrophobic
Pramlintide analogue San45 I198 2.64x64 TM2 Van der Waals
Pramlintide analogue San45 I199 2.65x65 TM2 hydrophobic
Pramlintide analogue San45 H201 2.67x67 TM2 Van der Waals
Pramlintide analogue San45 V203 2.69x69 TM2 hydrophobic
Pramlintide analogue San45 V203 2.69x69 TM2 Van der Waals
Pramlintide analogue San45 V206 ECL1 hydrophobic
Pramlintide analogue San45 V206 ECL1 Van der Waals
Pramlintide analogue San45 P207 ECL1 Van der Waals
Pramlintide analogue San45 P207 ECL1 polar (hydrogen bond with backbone)
Pramlintide analogue San45 N208 ECL1 Van der Waals
Pramlintide analogue San45 G209 ECL1 Van der Waals
Pramlintide analogue San45 E210 ECL1 Van der Waals
Pramlintide analogue San45 V212 ECL1 hydrophobic
Pramlintide analogue San45 V212 ECL1 Van der Waals
Pramlintide analogue San45 R213 ECL1 polar (charge-assisted hydrogen bond)
Pramlintide analogue San45 H226 3.36x36 TM3 polar (hydrogen bond)
Pramlintide analogue San45 M230 3.40x40 TM3 polar (hydrogen bond)
Pramlintide analogue San45 Y234 3.44x44 TM3 polar (hydrogen bond)
Pramlintide analogue San45 L291 45.52x52 ECL2 polar (hydrogen bond with backbone)
Pramlintide analogue San45 L291 45.52x52 ECL2 Van der Waals
Pramlintide analogue San45 S292 ECL2 Van der Waals
Pramlintide analogue San45 V293 ECL2 Van der Waals
Pramlintide analogue San45 V293 ECL2 polar (hydrogen bond with backbone)
Pramlintide analogue San45 E294 ECL2 polar (hydrogen bond with backbone)
Pramlintide analogue San45 E294 ECL2 polar (charge-assisted hydrogen bond)
Pramlintide analogue San45 Y299 5.37x38 TM5 Van der Waals
Pramlintide analogue San45 H302 5.40x40 TM5 polar (hydrogen bond)
Pramlintide analogue San45 V305 5.43x43 TM5 Van der Waals
Pramlintide analogue San45 M306 5.44x44 TM5 Van der Waals
Pramlintide analogue San45 F356 6.53x53 TM6 hydrophobic
Pramlintide analogue San45 F356 6.53x53 TM6 Van der Waals
Pramlintide analogue San45 P360 ECL3 Van der Waals
Pramlintide analogue San45 W361 ECL3 polar (hydrogen bond)
Pramlintide analogue San45 R362 ECL3 polar (hydrogen bond with backbone)
Pramlintide analogue San45 R362 ECL3 Van der Waals
Pramlintide analogue San45 Y372 7.38x37 TM7 polar (hydrogen bond)
Pramlintide analogue San45 D373 7.39x38 TM7 polar (charge-assisted hydrogen bond)
Pramlintide analogue San45 H377 7.43x42 TM7 polar (hydrogen bond)
Pramlintide analogue San45 I380 7.46x45 TM7 Van der Waals
Pramlintide analogue San45 H381 7.47x46 TM7 polar (hydrogen bond)

Ligands

Pramlintide analogue San45

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Residue Diagrams

V L T F I S L S H G V I A L Y Y L V Y A 1 K N M F L T Y I L N S M I I I I H L V E 2 C L M W F Y N C A M M Y Q H F F H L I K 3 R L R W Y Y L G L W G F P L V P T T I H A 4 L F F F N V V L A A M V P G H I I Y L 5 M I L V P L L G I Q F V V F P W 6 T A V F F G Q F H I L S H M V Y D Y I 7
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ICL1 R S L G ICL1ECL1 V P N G E L V R R D ECL1ICL2 A V F T E K Q ICL2ECL2 N D N C W L S V E T H L ECL2ICL3 E ICL3ECL3 R P S ECL3N-term M R F T F T S R C L A L F L L L N H P T P I L P A F S N Q T Y P T I E P K P F L Y V V G R K K M M D A Q Y K C Y D R M Q Q L P A Y Q G E G P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D E K G V W F K H P E N N R T W S N Y N-termC-term P S N R S A R A A A A A A E A G D I P I Y I C H Q E L R N E P A N N Q G E E S A E I I P L N I I E Q E S S A C-term T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V K R F K I R W G V Q T T Q W A Q Q W N Q R R
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Residue Table


GPCRdb(A)
GPCRdb(B)
CT receptor
TM1
1x29 1.33x33 L142
1x32 1.36x36 A145
1x33 1.37x37 Y146
1x35 1.39x39 L148
1x36 1.40x40 Y149
1x37 1.41x41 Y150
1x40 1.44x44 I153
1x43 1.47x47 H156
1x44 1.48x48 S157
1x47 1.51x51 I160
1x48 1.52x52 F161
TM2
2x57 2.64x64 I198
2x58 2.65x65 I199
2x60 2.67x67 H201
2x62 2.69x69 V203
TM3
3x32 3.36x36 H226
3x36 3.40x40 M230
3x40 3.44x44 Y234
ECL2
45x52 45.52x52 L291
TM5
5x42 5.37x38 Y299
5x44 5.40x40 H302
5x47 5.43x43 V305
5x48 5.44x44 M306
TM6
6x48 6.53x53 F356
TM7
7x33 7.38x37 Y372
7x34 7.39x38 D373
7x38 7.43x42 H377
7x41 7.46x45 I380
7x42 7.47x46 H381