Structure information

BB2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8H0Q

SPECIES

Homo sapiens

RESOLUTION

3.300

PREFERRED CHAIN

R

REFERENCE

10.1038/S41422-022-00743-6

PUBLICATION DATE

Aug. 9, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Gastrin-releasing peptide R100 2.64x63 TM2 polar (charge-assisted hydrogen bond)
Gastrin-releasing peptide Y101 2.65x64 TM2 hydrophobic
Gastrin-releasing peptide Y101 2.65x64 TM2 Van der Waals
Gastrin-releasing peptide D104 ECL1 polar (hydrogen bond with backbone)
Gastrin-releasing peptide D104 ECL1 Van der Waals
Gastrin-releasing peptide R105 23.49x49 ECL1 Van der Waals
Gastrin-releasing peptide W106 23.50x50 ECL1 Van der Waals
Gastrin-releasing peptide W106 23.50x50 ECL1 hydrophobic
Gastrin-releasing peptide P117 3.29x29 TM3 Van der Waals
Gastrin-releasing peptide P117 3.29x29 TM3 hydrophobic
Gastrin-releasing peptide V124 3.36x36 TM3 hydrophobic
Gastrin-releasing peptide F193 ECL2 hydrophobic
Gastrin-releasing peptide F193 ECL2 Van der Waals
Gastrin-releasing peptide S195 ECL2 polar (hydrogen bond)
Gastrin-releasing peptide S195 ECL2 Van der Waals
Gastrin-releasing peptide P198 45.52x52 ECL2 Van der Waals
Gastrin-releasing peptide P198 45.52x52 ECL2 hydrophobic
Gastrin-releasing peptide W277 6.48x48 TM6 Van der Waals
Gastrin-releasing peptide N280 6.51x51 TM6 Van der Waals
Gastrin-releasing peptide N280 6.51x51 TM6 polar (hydrogen bond)
Gastrin-releasing peptide Y284 6.55x55 TM6 hydrophobic
Gastrin-releasing peptide Y284 6.55x55 TM6 Van der Waals
Gastrin-releasing peptide R287 6.58x58 TM6 polar (charge-assisted hydrogen bond)
Gastrin-releasing peptide T296 ECL3 Van der Waals
Gastrin-releasing peptide T296 ECL3 polar (hydrogen bond)
Gastrin-releasing peptide H300 7.31x30 TM7 Van der Waals
Gastrin-releasing peptide F301 7.32x31 TM7 hydrophobic
Gastrin-releasing peptide F301 7.32x31 TM7 Van der Waals
Gastrin-releasing peptide R308 7.39x38 TM7 polar (charge-assisted hydrogen bond)

Ligands

Gastrin-releasing peptide

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Residue Diagrams

I N G I L G I L I I V G Y V A P I V Y L 1 S S L A L G D L L L L T I C A P V D A S R 2 A T L T F V S V G V S T L Q I F P I L K 3 I C L K A A F I W I I S M L L A I P E 4 Y Y V S I I S L P I V Y F V L F S A M S H 5 L V F V G L F A F C W L P N H V I Y L Y 6 F P N V C S N T F A L L R A C I S T V 7
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ICL1 K S M R ICL1ECL1 D R W L F ECL1ICL2 P M D I Q A S H ICL2ECL2 D L H P F H E E S T N Q T F I S C A P Y P H S ECL2ICL3 P V E G ICL3ECL3 Y S E V D T ECL3N-term M A L N D C F L L N L E V D H F M H C N I S S H S A D L P V N D D W S H N-termC-term C Q P G L I I R S H S T G R S T T C M T S L K S T N P S V A T F S L I N G N I C H E R Y V C-term P G I L Y V I P A V Y G V I I L I G L I G N I T L I K I F C T V N V P N L F I S S L A L G D L L L L I T C A P V D A S R Y L A G R I G C K L I P F I Q L T S V G V S V F T L T A L S A D R Y K A I V R A L M K I C L K A A F I W I I S M L L A I P E A V F S N E L H P K I H S M A S F L V F Y V I P L S I I S V Y Y Y F I A K N L I Q S A Y N L N I H V K K Q I E S R K R L A K T V L V F V G L F A F C W L P N H V I Y L Y R S Y H S M L H F V T S I C A R L L A F T N S C V N P F A L Y L L S K S F N T F R K Q Q L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
BB2 receptor
TM2
2x63 2.64x63 R100
2x64 2.65x64 Y101
ECL1
23x49 23.49x49 R105
23x50 23.50x50 W106
TM3
3x29 3.29x29 P117
3x36 3.36x36 V124
ECL2
45x52 45.52x52 P198
TM6
6x48 6.48x48 W277
6x51 6.51x51 N280
6x55 6.55x55 Y284
6x58 6.58x58 R287
TM7
7x30 7.31x30 H300
7x31 7.32x31 F301
7x38 7.39x38 R308