BB2 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8H0Q

RESOLUTION

3.3 Å

REFERENCE

10.1038/S41422-022-00743-6

PUBLICATION DATE

Aug. 9, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

62 interactions (Click to see)

LIGANDS

Gastrin-releasing peptide - Agonist pubchem

ENDOGENOUS LIGANDS

neuromedin B, gastrin releasing peptide(14-27) (human), gastrin-releasing peptide, neuromedin C, GRP-(18-27)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 145 - G.H5 L 349 G.H5.16
Hydrophobic TM2 P 75 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 P 75 2x39 G.H5 Y 356 G.H5.23
Polar TM6 R 259 6x30 G.H5 Q 350 G.H5.18
Van-der-waals TM6 R 259 6x30 G.H5 Q 350 G.H5.18
Hydrophobic ICL3 L 244 - G.H5 D 346 G.H5.14
Van-der-waals ICL3 L 244 - G.H5 D 346 G.H5.14
Polar ICL4 S 326 - G.H5 V 359 G.H5.26
Hydrophobic ICL4 S 326 - G.H5 V 359 G.H5.26
Van-der-waals ICL4 S 326 - G.H5 V 359 G.H5.26
Polar ICL2 P 145 - G.H5 N 352 G.H5.19
Van-der-waals ICL2 P 145 - G.H5 N 352 G.H5.19
Hydrophobic ICL3 L 244 - G.S6 Y 325 G.S6.03
Hydrophobic ICL3 G 248 - G.H4 V 314 G.H4.16
Hydrophobic ICL2 M 146 - G.H5 F 341 G.H5.09
Van-der-waals ICL2 M 146 - G.H5 F 341 G.H5.09
Polar ICL1 N 73 - G.H5 E 355 G.H5.22
Polar TM6 N 249 6x20 G.S6 C 324 G.S6.02
Van-der-waals TM6 N 249 6x20 G.S6 C 324 G.S6.02
Hydrophobic ICL2 P 145 - G.H5 K 345 G.H5.12
Van-der-waals ICL2 P 145 - G.H5 K 345 G.H5.12
Hydrophobic ICL2 S 151 - G.HN K 33 G.HN.51
Van-der-waals ICL2 S 151 - G.HN K 33 G.HN.51
Polar ICL2 H 152 - G.HN Q 30 G.HN.48
Van-der-waals TM3 I 142 3x54 G.H5 L 349 G.H5.16
Hydrophobic TM6 L 262 6x33 G.H5 L 353 G.H5.21
Hydrophobic TM2 P 75 2x39 G.H5 E 355 G.H5.22
Hydrophobic ICL2 M 146 - G.H5 C 344 G.H5.12
Hydrophobic ICL3 P 245 - G.S6 Y 325 G.S6.03
Hydrophobic ICL3 E 247 - G.S6 P 326 G.S6.04
Van-der-waals ICL3 E 247 - G.S6 P 326 G.S6.04
Hydrophobic TM6 Q 255 6x26 G.S6 I 323 G.S6.01
Hydrophobic TM7 L 322 7x53 G.H5 L 358 G.H5.25
Hydrophobic TM3 R 138 3x50 G.H5 L 358 G.H5.25
Hydrophobic ICL2 A 150 - G.hns1 R 37 G.hns1.02
Polar ICL4 S 326 - G.H5 L 358 G.H5.25
Hydrophobic ICL4 S 326 - G.H5 L 358 G.H5.25
Van-der-waals ICL4 S 326 - G.H5 L 358 G.H5.25
Hydrophobic ICL2 P 145 - G.H5 I 348 G.H5.15
Van-der-waals ICL2 P 145 - G.H5 I 348 G.H5.15
Hydrophobic TM6 H 251 6x22 G.S6 I 323 G.S6.01
Hydrophobic TM6 V 252 6x23 G.S6 I 323 G.S6.01
Van-der-waals TM6 V 252 6x23 G.S6 I 323 G.S6.01
Polar TM6 S 258 6x29 G.H5 V 359 G.H5.26
Hydrophobic TM6 S 258 6x29 G.H5 V 359 G.H5.26
Van-der-waals TM6 S 258 6x29 G.H5 V 359 G.H5.26
Hydrophobic TM3 I 142 3x54 G.H5 L 358 G.H5.25
Polar TM3 A 141 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 A 141 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 141 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM6 R 259 6x30 G.H5 L 353 G.H5.21
Van-der-waals TM6 R 259 6x30 G.H5 L 353 G.H5.21
Hydrophobic TM6 N 249 6x20 G.H4 V 314 G.H4.16
Van-der-waals TM6 N 249 6x20 G.H4 V 314 G.H4.16
Hydrophobic TM3 A 141 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 141 3x53 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 M 146 - G.H5 I 348 G.H5.15
Van-der-waals ICL2 M 146 - G.H5 I 348 G.H5.15
Hydrophobic ICL3 P 245 - G.S6 H 327 G.S6.04
Van-der-waals ICL3 P 245 - G.S6 H 327 G.S6.04
Hydrophobic ICL2 M 146 - G.H5 K 345 G.H5.12
Van-der-waals ICL2 M 146 - G.H5 K 345 G.H5.12
Hydrophobic ICL2 M 146 - G.S1 L 40 G.S1.02
Van-der-waals ICL2 M 146 - G.S1 L 40 G.S1.02
Hydrophobic ICL3 E 247 - G.H4 R 310 G.H4.13
Ionic TM6 R 259 6x30 G.H5 D 346 G.H5.14
Polar TM6 R 259 6x30 G.H5 D 346 G.H5.14
Polar ICL2 S 151 - G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 S 151 - G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 S 151 - G.hns1 R 37 G.hns1.02
Hydrophobic TM3 I 142 3x54 G.H5 L 353 G.H5.21
Polar ICL2 Q 149 - G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 Q 149 - G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 Q 149 - G.hns1 R 38 G.hns1.03
Hydrophobic TM6 R 259 6x30 G.H5 L 349 G.H5.16
Van-der-waals TM6 R 259 6x30 G.H5 L 349 G.H5.16
Polar ICL4 S 326 - G.H5 N 357 G.H5.24
Hydrophobic ICL4 S 326 - G.H5 N 357 G.H5.24
Van-der-waals ICL4 S 326 - G.H5 N 357 G.H5.24
Polar TM3 D 137 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 D 137 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 D 137 3x49 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 M 146 - G.S3 V 199 G.S3.02
Hydrophobic ICL2 Q 149 - G.S1 L 40 G.S1.02
Hydrophobic TM7 L 322 7x53 G.H5 N 357 G.H5.24
Hydrophobic TM7 L 325 7x56 G.H5 L 358 G.H5.25
Hydrophobic TM6 L 262 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 L 262 6x33 G.H5 L 358 G.H5.25
Polar ICL2 S 151 - G.HN Q 34 G.HN.52
Hydrophobic ICL2 S 151 - G.HN Q 34 G.HN.52
Van-der-waals ICL2 S 151 - G.HN Q 34 G.HN.52
Van-der-waals ICL2 Q 149 - G.H5 I 348 G.H5.15