Structure information

CXCR3

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8HNK

SPECIES

Homo sapiens

RESOLUTION

3.010

PREFERRED CHAIN

R

REFERENCE

10.1038/S41594-023-01175-5

PUBLICATION DATE

Nov. 29, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CXCL11 S40 N-term polar (hydrogen bond with backbone)
CXCL11 S40 N-term Van der Waals
CXCL11 S40 N-term polar (hydrogen bond)
CXCL11 P41 N-term Van der Waals
CXCL11 P42 N-term Van der Waals
CXCL11 P42 N-term polar (hydrogen bond with backbone)
CXCL11 C43 N-term Van der Waals
CXCL11 D52 1.31x31 TM1 polar (charge-assisted hydrogen bond)
CXCL11 W109 2.60x60 TM2 hydrophobic
CXCL11 W109 2.60x60 TM2 Van der Waals
CXCL11 F131 3.32x32 TM3 Van der Waals
CXCL11 F131 3.32x32 TM3 aromatic (edge-to-face)
CXCL11 N132 3.33x33 TM3 Van der Waals
CXCL11 F135 3.36x36 TM3 Van der Waals
CXCL11 F135 3.36x36 TM3 aromatic (face-to-edge)
CXCL11 E196 ECL2 Van der Waals
CXCL11 R197 ECL2 polar (charge-assisted hydrogen bond)
CXCL11 H202 ECL2 Van der Waals
CXCL11 C203 45.50x50 ECL2 Van der Waals
CXCL11 Q204 45.51x51 ECL2 Van der Waals
CXCL11 Q204 45.51x51 ECL2 polar (hydrogen bond)
CXCL11 Y205 45.52x52 ECL2 Van der Waals
CXCL11 Y205 45.52x52 ECL2 hydrophobic
CXCL11 N206 ECL2 Van der Waals
CXCL11 N206 ECL2 polar (hydrogen bond with backbone)
CXCL11 F207 ECL2 polar (hydrogen bond with backbone)
CXCL11 F207 ECL2 Van der Waals
CXCL11 P208 5.31x32 TM5 polar (hydrogen bond with backbone)
CXCL11 P208 5.31x32 TM5 Van der Waals
CXCL11 Q209 5.32x33 TM5 Van der Waals
CXCL11 R212 5.35x36 TM5 polar (charge-assisted hydrogen bond)
CXCL11 L215 5.38x39 TM5 hydrophobic
CXCL11 L215 5.38x39 TM5 Van der Waals
CXCL11 R216 5.39x40 TM5 Van der Waals
CXCL11 Q219 5.42x43 TM5 Van der Waals
CXCL11 Y271 6.51x51 TM6 hydrophobic
CXCL11 Y271 6.51x51 TM6 Van der Waals
CXCL11 D282 6.62x62 TM6 polar (charge-assisted hydrogen bond)
CXCL11 R288 ECL3 Van der Waals
CXCL11 E293 7.28x27 TM7 polar (charge-assisted hydrogen bond)
CXCL11 S304 7.39x38 TM7 polar (hydrogen bond)
CXCL11 Y308 7.43x42 TM7 polar (hydrogen bond)

Ligands

CXCL11

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Residue Diagrams

G N G L L G L L F L L S Y L A P L F A R 1 L H L A V A D T L L V L T L P L W A V D 2 C A L L L A G A Y F N I N F L A G A V K 3 V T L T C L A V W G L C L L F A L P D 4 Y C Y A M V L L P L L F G A V L Q L V R L 5 V V V V V A F A L C W T P Y H L V V L V 6 L P N L C C H M Y G L G S T V S K A V 7
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ICL1 R T A L ICL1ECL1 Q W V F ECL1ICL2 A T Q L Y R R G P P ICL2ECL2 S A H H D E R L N A T H C Q Y N F ECL2ICL3 R G Q ICL3ECL3 A L A R ECL3N-term M V L E V S D H Q V L N D A E V A A L L E N F S S S Y D Y G E N E S D S C C T S P P C P N-termC-term G C P N Q R G L Q R Q P S S S R R D S S W S E T S E A S Y S G L C-term Q D F S L N F D R A F L P A L Y S L L F L L G L L G N G A V A A V L L S R S S T D T F L L H L A V A D T L L V L T L P L W A V D A A V G S G L C K V A G A L F N I N F Y A G A L L L A C I S F D R Y L N I V H A R V T L T C L A V W G L C L L F A L P D F I F L P Q V G R T A L R V L Q L V A G F L L P L L V M A Y C Y A H I L A V L L V S R R L R A M R L V V V V V V A F A L C W T P Y H L V V L V D I L M D L G N C G R E S R V D V A K S V T S G L G Y M H C C L N P L L Y A F V G V K M W M L F R E R L L L R
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Residue Table


GPCRdb(A)
GPCRdb(A)
CXCR3
TM1
1x31 1.31x31 D52
TM2
2x60 2.60x60 W109
TM3
3x32 3.32x32 F131
3x33 3.33x33 N132
3x36 3.36x36 F135
ECL2
45x50 45.50x50 C203
45x51 45.51x51 Q204
45x52 45.52x52 Y205
TM5
5x32 5.31x32 P208
5x33 5.32x33 Q209
5x36 5.35x36 R212
5x39 5.38x39 L215
5x40 5.39x40 R216
5x43 5.42x43 Q219
TM6
6x51 6.51x51 Y271
6x62 6.62x62 D282
TM7
7x27 7.28x27 E293
7x38 7.39x38 S304
7x42 7.43x42 Y308