Structure information

CXCR1

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8IC0

SPECIES

Homo sapiens

RESOLUTION

3.410

PREFERRED CHAIN

A

REFERENCE

10.1038/S41467-023-39799-2

PUBLICATION DATE

July 19, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Interleukin-8 P22 N-term Van der Waals
Interleukin-8 P22 N-term polar (hydrogen bond with backbone)
Interleukin-8 D26 N-term polar (charge-assisted hydrogen bond)
Interleukin-8 Y27 N-term Van der Waals
Interleukin-8 Y27 N-term polar (hydrogen bond with backbone)
Interleukin-8 S28 N-term polar (hydrogen bond)
Interleukin-8 S28 N-term Van der Waals
Interleukin-8 P29 N-term Van der Waals
Interleukin-8 P29 N-term hydrophobic
Interleukin-8 Y178 ECL2 hydrophobic
Interleukin-8 Y178 ECL2 Van der Waals
Interleukin-8 N181 ECL2 Van der Waals
Interleukin-8 S184 ECL2 polar (hydrogen bond with backbone)
Interleukin-8 S184 ECL2 Van der Waals
Interleukin-8 V186 ECL2 Van der Waals
Interleukin-8 V186 ECL2 hydrophobic
Interleukin-8 Y188 45.51x51 ECL2 hydrophobic
Interleukin-8 Y188 45.51x51 ECL2 Van der Waals
Interleukin-8 N193 ECL2 polar (hydrogen bond)
Interleukin-8 N193 ECL2 Van der Waals
Interleukin-8 T195 5.31x32 TM5 polar (hydrogen bond)
Interleukin-8 T195 5.31x32 TM5 Van der Waals
Interleukin-8 R203 5.39x40 TM5 polar (charge-assisted hydrogen bond)
Interleukin-8 D265 6.58x58 TM6 polar (charge-assisted hydrogen bond)
Interleukin-8 R269 6.62x62 TM6 polar (charge-assisted hydrogen bond)
Interleukin-8 R280 7.28x27 TM7 polar (charge-assisted hydrogen bond)
Interleukin-8 L287 7.35x34 TM7 Van der Waals
Interleukin-8 D288 7.36x35 TM7 Van der Waals
Interleukin-8 E291 7.39x38 TM7 Van der Waals

Ligands

Interleukin-8

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Residue Diagrams

S N G L L S L L F V L A Y A I I V V Y K 1 L N L A L A D L L F A L T L P I W A A S 2 C A L L L I G S Y F N V E K L L S V V K 3 V K F V C L G C W G L S M N L S L P F 4 Y C F L M V F L P V I F G F T H P L I R L 5 F A V V L I F L L C W L P Y N L V L L A 6 I P N L C S H L F G L I E T A D L A R 7
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ICL1 R V G R ICL1ECL1 G W I F ECL1ICL2 A T R T L T Q K R H ICL2ECL2 Q A Y H P N N S S P V C Y E V L G N ECL2ICL3 H M G ICL3ECL3 V I Q E ECL3N-term M S N I T D P Q M W D F D D L N F T G M P P A D E D Y S P C M L E T E N-termC-term G L V S K E F L A R H R V T S Y T S S S V N V S S N L C-term T L N K Y V V I I A Y A L V F L L S L L G N S L V M L V I L Y S S V T D V Y L L N L A L A D L L F A L T L P I W A A S K V N G T F L C K V V S L L K E V N F Y S G I L L L A C I S V D R Y L A I V H L V K F V C L G C W G L S M N L S L P F F L F R D T A K W R M V L R I L P H T F G F I V P L F V M L F C Y G F T L R T L F K A Q K H R A M R V I F A V V L I F L L C W L P Y N L V L L A D T L M R T Q S C E R R N N I G R A L D A T E I L G F L H S C L N P I I Y A F I G Q N F L K H F R H G I L A M
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Residue Table


GPCRdb(A)
GPCRdb(A)
CXCR1
ECL2
45x51 45.51x51 Y188
TM5
5x32 5.31x32 T195
5x40 5.39x40 R203
TM6
6x58 6.58x58 D265
6x62 6.62x62 R269
TM7
7x27 7.28x27 R280
7x34 7.35x34 L287
7x35 7.36x35 D288
7x38 7.39x38 E291