Structure information

TA1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8WC8

SPECIES

Homo sapiens

RESOLUTION

2.900

PREFERRED CHAIN

R

REFERENCE

10.1016/J.CELL.2023.10.014

PUBLICATION DATE

Dec. 27, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL476516 D103 3.32x32 TM3 polar (charge-assisted hydrogen bond)
CHEMBL476516 I104 3.33x33 TM3 hydrophobic
CHEMBL476516 I104 3.33x33 TM3 Van der Waals
CHEMBL476516 S107 3.36x36 TM3 Van der Waals
CHEMBL476516 S107 3.36x36 TM3 polar (hydrogen bond)
CHEMBL476516 T194 5.42x43 TM5 polar (hydrogen bond)
CHEMBL476516 W264 6.48x48 TM6 Van der Waals
CHEMBL476516 W264 6.48x48 TM6 hydrophobic
CHEMBL476516 F267 6.51x51 TM6 aromatic (edge-to-face)
CHEMBL476516 F267 6.51x51 TM6 Van der Waals
CHEMBL476516 F268 6.52x52 TM6 hydrophobic
CHEMBL476516 F268 6.52x52 TM6 Van der Waals
CHEMBL476516 I290 7.39x38 TM7 Van der Waals
CHEMBL476516 Y294 7.43x42 TM7 polar (hydrogen bond)

Ligands

CHEMBL476516

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Residue Diagrams

L N G V L T T L I I L V M L S Y L S A R 1 H S M A T V D F L L G L C V M P Y S M V R 2 F S L H F I S A S S L M I D T S T H I K 3 I C V M I F I S W S V P A V F A F G M I 4 Y V C L M I S G P I Y F S T M F T L V G S 5 G I V M G V F L I C W C P F F I C T V M 6 M P N F T S N L Y G F W I L V D N L T 7
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ICL1 K Q L H ICL1ECL1 C W Y F ECL1ICL2 P L R Y K A K M ICL2ECL2 L N F K G A E E I Y Y K H V H C R G G C S V F F ECL2ICL3 I G L E M K ICL3ECL3 H Y I I ECL3N-term M M P F C H N I I N I S C V K N N W S N N-termC-term G K I F Q K D S S R C K L F L E L S S C-term D V R A S L Y S L M V L I I L T T L V G N L I V I V S I S H F T P T N W L I H S M A T V D F L L G C L V M P Y S M V R S A E H G E V F C K I H T S T D I M L S S A S I F H L S F I S I D R Y Y A V C D N I L V I C V M I F I S W S V P A V F A F G M I F L E S K I S G V L T F M T S F Y I P G S I M L C V Y Y R I Y L I A K E Q A R L I S D A N Q K L Q N G I S Q S K E R K A V K T L G I V M G V F L I C W C P F F I C T V M D P F L P P T L N D V L I W F G Y L N S T F N P M V Y A F F Y P W L K M F R K A M L F
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Residue Table


GPCRdb(A)
GPCRdb(A)
TA1 receptor
TM3
3x32 3.32x32 D103
3x33 3.33x33 I104
3x36 3.36x36 S107
TM5
5x43 5.42x43 T194
TM6
6x48 6.48x48 W264
6x51 6.51x51 F267
6x52 6.52x52 F268
TM7
7x38 7.39x38 I290
7x42 7.43x42 Y294