PDB
8YYW
Resolution
3.2 Å
Released
April 9, 2025
Receptor
oxoglutarate
Class
A
Species
Homo sapiens
Ligand
α-ketoglutaric acid
Function
Agonist
Reference
10.1038/S41467-025-67101-Z

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Ligand Amino Acid Generic Number Segment Interaction Type
α-ketoglutaric acid R110 3.29x29 TM3 polar (charge-assisted hydrogen bond)
α-ketoglutaric acid F113 3.32x32 TM3 hydrophobic
α-ketoglutaric acid F113 3.32x32 TM3 Van der Waals
α-ketoglutaric acid H114 3.33x33 TM3 polar (hydrogen bond)
α-ketoglutaric acid H114 3.33x33 TM3 Van der Waals
α-ketoglutaric acid D185 45.52x52 ECL2 Van der Waals
α-ketoglutaric acid L186 ECL2 Van der Waals
α-ketoglutaric acid T187 ECL2 Van der Waals
α-ketoglutaric acid R261 6.55x55 TM6 polar (charge-assisted hydrogen bond)
α-ketoglutaric acid Y284 7.35x34 TM7 polar (hydrogen bond)
α-ketoglutaric acid Y284 7.35x34 TM7 polar (hydrogen bond)
α-ketoglutaric acid R288 7.39x38 TM7 polar (charge-assisted hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 M R P W ICL1ECL1 G E N W I F ECL1ICL2 P M S C F S I H ICL2ECL2 T S T N R T N R S A C L D L T S S D E ECL2ICL3 G L Q T ICL3ECL3 R L L S I ECL3N-term M N E P L D Y L A N A S D F P D Y A A A F G N C T D E N I P N-termC-term C K V S G N L E Q A K K I S Y S N N P C-term L K M H Y L P V I Y G I I F L V G F P G N A V V I S T Y I F K K S S T I I M L N L A C T D L L Y L T S L P F L I H Y Y A S G D F M C K F I R F S F H F N L Y S S I L F L T C F S I F R Y C V I I H K T R C A V V A C A V V W I I S L V A V I P M T F L I L N T I K W Y N L I L T A T T F C L P L V I V T L C Y T T I I H T L T H D S C L K Q K A R R L T I L L L L A F Y V C F L P F H I L R V I R I E S S C S I E N Q I H E A Y I V S R P L A A L N T F G N L L L Y V V V S D N V C S F Q Q A T V R
Helix box plot — Download: PNG | SVG A N G P F G V L F I I G Y I V P L Y H M 1 L N L A C T D L L Y L T S L P F L I H Y 2 C T L F L I S S Y L N F H F S F R I F K 3 A V V A C A V V W I I S L V A V I P M 4 Y C L T V I V L P L C F T T A T L I L N Y 5 I L L L L A F Y V C F L P F H I L R V I 6 L L N G F T N L A A L P R S V I Y A E 7

GPCRdb(A)
GPCRdb(A)
oxoglutarate receptor
TM3
3x29 3.29x29 R110
3x32 3.32x32 F113
3x33 3.33x33 H114
ECL2
45x52 45.52x52 D185
TM6
6x55 6.55x55 R261
TM7
7x34 7.35x34 Y284
7x38 7.39x38 R288