oxoglutarate receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

E

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8YYW

RESOLUTION

3.2 Å

REFERENCE

10.1038/S41467-025-67101-Z

PUBLICATION DATE

April 9, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

25 interactions (Click to see)

LIGANDS

α-ketoglutaric acid - Agonist pubchem gtoplig chembl_ligand drugbank

PHYSIOLOGICAL LIGANDS

α-ketoglutaric acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 246 6x40 G.H5 L 353 G.H5.20
Hydrophobic TM3 F 130 3x49 G.H5 Y 351 G.H5.18
Ionic TM6 K 236 6x30 G.H5 D 341 G.H5.08
Polar TM6 K 236 6x30 G.H5 D 341 G.H5.08
Hydrophobic TM2 S 68 2x39 G.H5 Y 351 G.H5.18
Polar H8 N 308 8x49 G.H5 K 349 G.H5.16
Hydrophobic H8 N 308 8x49 G.H5 K 349 G.H5.16
Van-der-waals H8 N 308 8x49 G.H5 K 349 G.H5.16
Hydrophobic TM5 L 225 5x65 G.H5 L 348 G.H5.15
Polar ICL3 S 233 - G.H5 Q 345 G.H5.12
Hydrophobic TM3 V 134 3x53 G.H5 Y 351 G.H5.18
Van-der-waals TM3 V 134 3x53 G.H5 Y 351 G.H5.18
Hydrophobic ICL3 L 229 - G.H5 D 341 G.H5.08
Ionic ICL2 H 145 - G.H5 E 350 G.H5.17
Polar ICL2 H 145 - G.H5 E 350 G.H5.17
Polar TM3 V 134 3x53 G.H5 N 347 G.H5.14
Hydrophobic TM3 V 134 3x53 G.H5 N 347 G.H5.14
Van-der-waals TM3 V 134 3x53 G.H5 N 347 G.H5.14
Ionic H8 D 307 8x48 G.H5 K 349 G.H5.16
Polar H8 D 307 8x48 G.H5 K 349 G.H5.16
Hydrophobic H8 D 307 8x48 G.H5 K 349 G.H5.16
Van-der-waals H8 D 307 8x48 G.H5 K 349 G.H5.16
Hydrophobic ICL3 L 229 - G.h4s6 Y 320 G.h4s6.11
Van-der-waals ICL3 L 229 - G.h4s6 Y 320 G.h4s6.11
Polar TM2 S 68 2x39 G.H5 E 350 G.H5.17
Van-der-waals TM2 S 68 2x39 G.H5 E 350 G.H5.17
Hydrophobic TM3 R 131 3x50 G.H5 L 353 G.H5.20
Van-der-waals TM3 R 131 3x50 G.H5 L 353 G.H5.20
Polar ICL2 P 138 - G.H5 N 347 G.H5.14
Polar H8 S 306 8x47 G.H5 N 352 G.H5.19
Hydrophobic H8 S 306 8x47 G.H5 N 352 G.H5.19
Van-der-waals H8 S 306 8x47 G.H5 N 352 G.H5.19
Hydrophobic TM3 I 135 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 I 135 3x54 G.H5 L 353 G.H5.20
Polar TM7 Y 302 7x53 G.H5 N 352 G.H5.19
Hydrophobic ICL2 M 139 - G.S2 L 194 G.S2.06
Van-der-waals ICL2 M 139 - G.S2 L 194 G.S2.06
Hydrophobic TM5 L 225 5x65 G.H5 L 344 G.H5.11
Hydrophobic ICL2 P 138 - G.H5 I 343 G.H5.10
Hydrophobic TM6 A 239 6x33 G.H5 L 348 G.H5.15
Hydrophobic ICL2 M 139 - G.H5 V 339 G.H5.06
Hydrophobic ICL2 H 145 - G.H5 N 347 G.H5.14
Polar ICL3 Q 230 - G.H5 Q 345 G.H5.12
Van-der-waals ICL3 Q 230 - G.H5 Q 345 G.H5.12
Polar ICL3 Q 230 - G.h4s6 Y 320 G.h4s6.11
Hydrophobic ICL3 Q 230 - G.h4s6 Y 320 G.h4s6.11
Van-der-waals ICL3 Q 230 - G.h4s6 Y 320 G.h4s6.11
Hydrophobic TM6 L 235 6x29 G.h4s6 T 316 G.h4s6.01
Hydrophobic TM6 L 242 6x36 G.H5 L 353 G.H5.20
Hydrophobic TM3 F 127 3x46 G.H5 Y 351 G.H5.18
Van-der-waals TM3 F 127 3x46 G.H5 Y 351 G.H5.18
Hydrophobic ICL2 M 139 - G.H5 K 340 G.H5.07
Van-der-waals ICL2 M 139 - G.H5 K 340 G.H5.07
Hydrophobic ICL2 F 142 - G.HN R 32 G.HN.50
Van-der-waals ICL2 F 142 - G.HN R 32 G.HN.50
Hydrophobic ICL2 K 146 - G.HN E 28 G.HN.46
Polar TM3 R 131 3x50 G.H5 Y 351 G.H5.18
Hydrophobic TM3 R 131 3x50 G.H5 Y 351 G.H5.18
Van-der-waals TM3 R 131 3x50 G.H5 Y 351 G.H5.18
Hydrophobic TM6 L 235 6x29 G.H5 Q 345 G.H5.12
Polar TM6 A 239 6x33 G.H5 L 353 G.H5.20
Hydrophobic TM6 A 239 6x33 G.H5 L 353 G.H5.20
Van-der-waals TM6 A 239 6x33 G.H5 L 353 G.H5.20
Hydrophobic ICL1 K 66 - G.H5 E 350 G.H5.17
Hydrophobic ICL2 M 139 - G.H5 F 336 G.H5.03
Hydrophobic ICL2 P 138 - G.H5 K 340 G.H5.07
Polar TM4 T 147 4x39 G.HN E 28 G.HN.46
Polar ICL2 H 145 - G.HN R 32 G.HN.50
Aromatic ICL2 H 145 - G.HN R 32 G.HN.50
Hydrophobic ICL2 H 145 - G.HN R 32 G.HN.50
Van-der-waals ICL2 H 145 - G.HN R 32 G.HN.50
Hydrophobic TM3 I 135 3x54 G.H5 L 348 G.H5.15
Van-der-waals TM3 I 135 3x54 G.H5 L 348 G.H5.15
Hydrophobic TM6 K 236 6x30 G.H5 L 344 G.H5.11
Hydrophobic ICL2 F 142 - G.S2 L 194 G.S2.06
Van-der-waals ICL2 F 142 - G.S2 L 194 G.S2.06
Polar ICL3 C 234 - G.H4 D 315 G.H4.17
Hydrophobic ICL3 C 234 - G.H4 D 315 G.H4.17
Van-der-waals ICL3 C 234 - G.H4 D 315 G.H4.17
Hydrophobic ICL2 P 138 - G.H5 L 344 G.H5.11
Hydrophobic TM6 K 238 6x32 G.H5 V 354 G.H5.21
Van-der-waals TM6 K 238 6x32 G.H5 V 354 G.H5.21
Hydrophobic ICL3 Q 230 - G.h4s6 E 318 G.h4s6.09
Hydrophobic TM6 L 235 6x29 G.H5 V 354 G.H5.21
Van-der-waals TM6 L 235 6x29 G.H5 V 354 G.H5.21
Hydrophobic ICL2 M 139 - G.H5 I 343 G.H5.10
Van-der-waals ICL2 M 139 - G.H5 I 343 G.H5.10