raclopride


SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl
InChIKey WAOQONBSWFLFPE-VIFPVBQESA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 5
Molecular weight (Da) 346.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Ligand site mutations D1 D2 D3 D4

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.2 5.2 5.2 Guide to Pharmacology
D2 DRD2 Human Dopamine A pKi 8.0 8.0 8.0 Guide to Pharmacology
D3 DRD3 Human Dopamine A pKi 7.9 7.9 7.9 Guide to Pharmacology
D4 DRD4 Rat Dopamine A pKi 5.7 5.7 5.7 Guide to Pharmacology
D2 DRD2 Rat Dopamine A pKi 7.7 8.5 9.3 Guide to Pharmacology
D2 DRD2 Rat Dopamine A pKd 8.9 8.9 8.9 Guide to Pharmacology
D2 DRD2 Rat Dopamine A pKi 7.48 8.51 8.96 ChEMBL
D2 DRD2 Rat Dopamine A pKd 8.15 8.68 8.96 ChEMBL
D3 DRD3 Human Dopamine A pKi 7.82 8.0 8.43 ChEMBL
D2 DRD2 Human Dopamine A pKi 7.51 8.0 8.92 ChEMBL
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 5.3 5.3 5.3 PDSP Ki database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 5.3 5.3 5.3 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 5.19 5.32 5.4 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 7.66 8.71 9.3 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 8.1 8.62 8.92 PDSP Ki database
D4 DRD4 Human Dopamine A pKi 5.39 5.86 6.21 PDSP Ki database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 5.3 5.3 5.3 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 6.87 8.16 9.0 PDSP Ki database
H1 HRH1 Rat Histamine A pKi 5.07 5.07 5.07 PDSP Ki database
β2 ADRB2 Rat Adrenoceptors A pKi 5.0 5.0 5.0 PDSP Ki database
D4 DRD4 Rat Dopamine A pKi 5.62 6.12 6.63 PDSP Ki database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 5.4 5.4 5.4 PDSP Ki database
D2 DRD2 Mouse Dopamine A pKi 8.32 8.32 8.32 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
D1 DRD1 Human Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
H1 HRH1 Human Histamine A pKi 5.07 5.07 5.07 PDSP Ki database
D4 DRD4 Human Dopamine A pKi 5.51 5.51 5.51 ChEMBL
D1 DRD1 Pig Dopamine A pKi 4.43 4.43 4.43 ChEMBL
D1 DRD1 Mouse Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D2 DRD2 Rat Dopamine A pIC50 7.5 7.92 8.89 ChEMBL
D2 DRD2 Human Dopamine A pIC50 6.98 7.87 8.74 ChEMBL