ropinirole


SMILES CCCN(CCC)CCc1cccc2c1CC(=N2)O
InChIKey UHSKFQJFRQCDBE-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 260.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D2 DRD2 Human Dopamine A pKi 8.14 8.14 8.14 Guide to Pharmacology
D3 DRD3 Human Dopamine A pKi 7.72 7.72 7.72 Guide to Pharmacology
D5 DRD5 Human Dopamine A pKi 4.38 4.38 4.38 ChEMBL
D2 DRD2 Rat Dopamine A pKi 5.57 5.57 5.57 ChEMBL
D4 DRD4 Human Dopamine A pKi 8.11 8.11 8.11 ChEMBL
D1 DRD1 Human Dopamine A pKi 4.49 4.49 4.49 ChEMBL
D3 DRD3 Human Dopamine A pKi 7.21 7.73 8.54 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.77 5.77 5.77 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.16 7.58 8.43 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.03 6.1 6.17 PDSP Ki database
α1B ADA1B Human Adrenoceptors A pKi 5.0 5.0 5.0 PDSP Ki database
α1D ADA1D Human Adrenoceptors A pKi 5.0 5.0 5.0 PDSP Ki database
D1 DRD1 Human Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 7.43 7.43 7.43 PDSP Ki database
D4 DRD4 Human Dopamine A pKi 6.07 6.07 6.07 PDSP Ki database
D5 DRD5 Human Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.54 6.54 6.54 PDSP Ki database
α2A ADA2A Human Adrenoceptors A pKi 5.73 5.73 5.73 PDSP Ki database
α2C ADA2C Human Adrenoceptors A pKi 5.92 5.92 5.92 PDSP Ki database
β1 ADRB1 Human Adrenoceptors A pKi 5.0 5.0 5.0 PDSP Ki database
β2 ADRB2 Human Adrenoceptors A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 5.86 5.86 5.86 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 5.42 5.42 5.42 PDSP Ki database
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
H1 HRH1 Guinea pig Histamine A pKi 5.53 5.53 5.53 PDSP Ki database
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
α2B ADA2B Human Adrenoceptors A pKi 6.12 6.12 6.12 PDSP Ki database
5-HT4 5HT4R Guinea pig 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 5.94 5.94 5.94 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.18 8.18 8.18 Drug Central
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 8.23 8.23 8.23 Drug Central
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.27 8.27 8.27 Drug Central
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 8.24 8.24 8.24 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.24 8.24 8.24 Drug Central
α2B ADA2B Human Adrenoceptors A pKi 8.21 8.21 8.21 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.23 8.23 8.23 Drug Central
D1 DRD1 Human Dopamine A pKi 8.35 8.35 8.35 Drug Central
D2 DRD2 Human Dopamine A pKi 8.09 8.09 8.09 Drug Central
D3 DRD3 Human Dopamine A pKi 8.13 8.13 8.13 Drug Central
D4 DRD4 Human Dopamine A pKi 8.22 8.22 8.22 Drug Central
D5 DRD5 Human Dopamine A pKi 8.36 8.36 8.36 Drug Central
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 5.82 5.82 5.82 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 8.25 8.25 8.25 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D2 DRD2 Bovine Dopamine A pIC50 5.17 5.17 5.17 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 4.75 4.8 4.85 ChEMBL
D2 DRD2 Rat Dopamine A pIC50 5.74 5.74 5.74 ChEMBL
D2 DRD2 Rat Dopamine A pEC50 7.12 7.12 7.12 ChEMBL
D3 DRD3 Human Dopamine A pEC50 7.72 8.03 8.4 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pEC50 6.85 6.85 6.85 ChEMBL
D2 DRD2 Human Dopamine A pEC50 6.48 6.87 8.19 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pEC50 8.16 8.16 8.16 Drug Central
D2 DRD2 Bovine Dopamine A pIC50 8.29 8.29 8.29 Drug Central