(R)-Ro65-6570


SMILES O=C1NCN(C21CCN(CC2)[C@@H]1Cc2c3c1cccc3ccc2)c1ccccc1
InChIKey BBOAHBVXCYBKLC-JOCHJYFZSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 2
Molecular weight (Da) 383.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
NOP OPRX Human Opioid A pKi 9.6 9.6 9.6 Guide to Pharmacology
NOP OPRX Rat Opioid A pKi 9.39 9.39 9.39 ChEMBL
κ OPRK Rat Opioid A pKi 7.7 7.7 7.7 ChEMBL
NOP OPRX Human Opioid A pKi 9.6 9.6 9.6 ChEMBL
μ OPRM Rat Opioid A pKi 8.4 8.4 8.4 ChEMBL
δ OPRD Human Opioid A pKi 7.0 7.0 7.0 ChEMBL
κ OPRK Human Opioid A pKi 7.7 7.7 7.7 ChEMBL
μ OPRM Human Opioid A pKi 8.4 8.4 8.4 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
NOP OPRX Human Opioid A pEC50 7.4 7.4 7.4 Guide to Pharmacology
NOP OPRX Human Opioid A pEC50 7.4 7.4 7.4 ChEMBL