CHEMBL28056


SMILES Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3
InChIKey APEZAWGOFKUHCA-JOCHJYFZSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 1
Molecular weight (Da) 350.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 7.68 8.23 8.42 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 7.68 8.38 9.0 ChEMBL
D2 DRD2 Rat Dopamine A pKi 5.6 6.07 6.3 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 6.85 6.85 6.85 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.11 6.6 6.85 ChEMBL
D2 DRD2 Human Dopamine A pKi 5.61 5.96 6.3 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database