RILMENIDINE


SMILES C1COC(NC(C2CC2)C2CC2)=N1
InChIKey CQXADFVORZEARL-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 3
Molecular weight (Da) 180.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α2B ADA2B Human Adrenoceptors A pKi 7.15 7.26 7.37 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 6.54 7.22 7.9 ChEMBL
α1A ADA1A Human Adrenoceptors A pKi 5.05 5.13 5.22 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 6.52 6.9 7.44 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 5.8 5.8 5.8 PDSP Ki database
α2B ADA2B Human Adrenoceptors A pKi 5.76 5.76 5.76 PDSP Ki database
α2C ADA2C Human Adrenoceptors A pKi 5.33 5.33 5.33 PDSP Ki database
α2A ADA2A Mouse Adrenoceptors A pKi 6.14 6.14 6.14 PDSP Ki database
α1A ADA1A Human Adrenoceptors A pKi 8.3 8.3 8.3 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.13 8.13 8.13 Drug Central
α2B ADA2B Human Adrenoceptors A pKi 8.13 8.13 8.13 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.1 8.1 8.1 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α2B ADA2B Human Adrenoceptors A pEC50 6.14 6.14 6.14 ChEMBL
α2C ADA2C Human Adrenoceptors A pEC50 6.72 6.72 6.72 ChEMBL
α2A ADA2A Human Adrenoceptors A pEC50 6.56 6.65 6.75 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 4.4 4.4 4.4 ChEMBL