PERLAPINE


SMILES CN1CCN(C2=Nc3ccccc3Cc3ccccc32)CC1
InChIKey PWRPUAKXMQAFCJ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 0
Molecular weight (Da) 291.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H4 HRH4 Human Histamine A pKi 5.32 5.32 5.32 ChEMBL
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 7.15 7.15 7.15 PDSP Ki database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 7.55 7.55 7.55 PDSP Ki database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 7.53 7.71 7.9 PDSP Ki database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 6.82 6.82 6.82 PDSP Ki database
D4 DRD4 Rat Dopamine A pKi 8.1 8.1 8.1 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 6.3 6.3 6.3 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.52 7.71 7.89 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 7.22 7.22 7.22 PDSP Ki database
D4 DRD4 Human Dopamine A pKi 7.52 7.52 7.52 PDSP Ki database
D3 DRD3 Rat Dopamine A pKi 6.04 6.04 6.04 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 7.0 7.0 7.0 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.11 8.11 8.11 Drug Central
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.17 8.17 8.17 Drug Central
D2 DRD2 Human Dopamine A pKi 8.14 8.14 8.14 Drug Central
D3 DRD3 Human Dopamine A pKi 8.15 8.15 8.15 Drug Central
D4 DRD4 Human Dopamine A pKi 8.12 8.12 8.12 Drug Central
H4 HRH4 Human Histamine A pKi 8.27 8.27 8.27 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D2 DRD2 Rat Dopamine A pIC50 5.57 5.57 5.57 ChEMBL
D2 DRD2 Rat Dopamine A pIC50 8.25 8.25 8.25 Drug Central