CHEMBL106737


SMILES COc1ccccc1N1CCN(CC2CN=C3c4ccccc4NC(=O)N32)CC1
InChIKey FUCGAUZSWYLMRK-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 4
Molecular weight (Da) 391.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α1B ADA1B Rat Adrenoceptors A pKi 9.17 9.17 9.17 ChEMBL
α1A ADA1A Rat Adrenoceptors A pKi 9.59 9.59 9.59 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 6.81 6.81 6.81 ChEMBL
D3 DRD3 Human Dopamine A pKi 6.01 6.01 6.01 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.62 6.71 6.8 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database