CHEMBL3394848


SMILES O=C(c1ccccc1-n1nccn1)N1CCC(F)(F)[C@@H](Oc2ccc3ccccc3n2)C1
InChIKey VCYRJXZNOOUBSE-FQEVSTJZSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 4
Molecular weight (Da) 435.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
OX1 OX1R Human Orexin A pKi 8.89 8.89 8.89 ChEMBL
OX2 OX2R Human Orexin A pKi 6.28 6.28 6.28 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
OX2 OX2R Human Orexin A pIC50 5.38 5.38 5.38 ChEMBL
OX1 OX1R Rat Orexin A pIC50 7.96 7.96 7.96 ChEMBL
OX2 OX2R Rat Orexin A pIC50 5.88 5.88 5.88 ChEMBL