CHEMBL365403


SMILES Cc1nc(C#Cc2cccc(-c3ccccc3)c2)cs1
InChIKey JWWDWRFQBGXCEK-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 1
Molecular weight (Da) 275.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Rat Metabotropic glutamate C pKi 7.8 7.8 7.8 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pKi 7.97 7.97 7.97 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Rat Metabotropic glutamate C pIC50 8.52 8.52 8.52 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pIC50 7.39 7.39 7.39 ChEMBL