ArrestinDb

cyclopamine

Agent/drug
Bioactivity

cyclopamine

SMILES	CC1=C2C[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@@]43C)[C@@H]2CC[C@]12O[C@@H]1C[C@H](C)CN[C@H]1[C@H]2C
InChIKey	QASFUMOKHFSJGL-LAFRSMQTSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	2
Rotatable bonds	0
Molecular weight (Da)	411.3

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Structure pdb	4O9R 6D32

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

SMO	SMO	Human	Frizzled	F	pKi	6.63	7.27	7.90	ChEMBL
SMO	SMO	Human	Frizzled	F	pKd	6.94	7.43	7.91	ChEMBL

Showing 1 to 2 of 2 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

SMO	SMO	Mouse	Frizzled	F	pIC50	5.72	5.95	6.32	ChEMBL
SMO	SMO	Human	Frizzled	F	pIC50	6.52	6.75	7.19	ChEMBL
SMO	SMO	Mouse	Frizzled	F	pIC50	7.00	7.00	7.00	Guide to Pharmacology

Showing 1 to 3 of 3 entries

cyclopamine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Structure pdb	4O9R 6D32

Compound is not listed as a drug.