CHEMBL365751


SMILES Cc1[nH]c2ccc(Cl)cc2c1CCN(C)C
InChIKey KSYMELKKLOFABL-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 3
Molecular weight (Da) 236.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Structure pdb 8JLZ
Ligand site mutations 5-HT6

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 7.54 7.54 7.54 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 6.54 6.54 6.54 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.61 6.61 6.61 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pIC50 7.4 7.4 7.4 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pEC50 7.35 7.35 7.35 ChEMBL