ArrestinDb

5-MeO-DMT

Agent/drug
Bioactivity

5-MeO-DMT

SMILES	COc1ccc2[nH]cc(CCN(C)C)c2c1
InChIKey	ZSTKHSQDNIGFLM-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	1
Rotatable bonds	4
Molecular weight (Da)	218.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank GPCRdb
Structure pdb	8FY8
Ligand site mutations	5-HT_1B 5-HT_2A 5-HT₆

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	7.16	7.86	8.26	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	7.55	7.55	7.55	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.72	8.72	8.72	PDSP Ki database
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	6.46	6.75	7.05	ChEMBL
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	7.13	7.38	7.63	PDSP Ki database
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	6.45	6.47	6.49	PDSP Ki database
5-HT_1D	F1MMU1	Bovine	5-Hydroxytryptamine	A	pKi	7.11	7.33	7.54	PDSP Ki database
5-HT_1D	5HT1D	Dog	5-Hydroxytryptamine	A	pKi	8.29	8.29	8.29	PDSP Ki database
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	8.20	8.20	8.20	PDSP Ki database
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	7.70	7.70	7.70	ChEMBL
5-HT_1E	5HT1E	Human	5-Hydroxytryptamine	A	pKi	6.10	6.20	6.30	Guide to Pharmacology
5-HT_1E	5HT1E	Human	5-Hydroxytryptamine	A	pKi	6.28	6.33	6.44	PDSP Ki database
5-HT_1F	5HT1F	Human	5-Hydroxytryptamine	A	pKi	7.43	7.43	7.43	PDSP Ki database
5-HT_1F	5HT1F	Human	5-Hydroxytryptamine	A	pKi	7.40	7.40	7.40	Guide to Pharmacology
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	6.21	7.28	7.82	ChEMBL
5-HT_2A	5HT2A	Bovine	5-Hydroxytryptamine	A	pKi	6.41	6.41	6.41	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	5.70	6.33	7.05	PDSP Ki database
5-HT_2B	5HT2B	Rat	5-Hydroxytryptamine	A	pKd	7.08	7.08	7.08	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	7.28	7.28	7.28	ChEMBL
5-HT_2B	F6QI78	Bovine	5-Hydroxytryptamine	A	pKi	5.89	5.89	5.89	PDSP Ki database

Showing 1 to 20 of 43 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	7.96	7.96	7.96	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pEC50	6.71	6.71	6.71	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pIC50	7.82	7.82	7.82	ChEMBL
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pIC50	6.26	6.26	6.26	ChEMBL
5-HT_1D	5HT1D	Guinea pig	5-Hydroxytryptamine	A	pIC50	7.31	7.31	7.31	ChEMBL
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pIC50	7.31	7.31	7.31	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pEC50	8.65	8.72	8.75	ChEMBL
5-HT_2B	5HT2B	Rat	5-Hydroxytryptamine	A	pEC50	6.62	6.62	6.62	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pEC50	8.09	8.16	8.23	ChEMBL
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pIC50	6.60	6.60	6.60	ChEMBL
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pEC50	7.11	7.11	7.11	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pEC50	7.44	7.47	7.51	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	6.60	6.60	6.60	ChEMBL
MT₁	MTR1A	Human	Melatonin	A	pEC50	6.59	6.59	6.59	ChEMBL
MT₂	MTR1B	Human	Melatonin	A	pEC50	6.95	6.95	6.95	ChEMBL

Showing 1 to 15 of 15 entries

5-MeO-DMT

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank GPCRdb
Structure pdb	8FY8
Ligand site mutations	5-HT_1B 5-HT_2A 5-HT₆

Compound is not listed as a drug.