ArrestinDb

dexmedetomidine

Agent/drug
Bioactivity

dexmedetomidine

SMILES	Cc1cccc([C@H](C)c2c[nH]cn2)c1C
InChIKey	CUHVIMMYOGQXCV-NSHDSACASA-N

Chemical Properties

Hydrogen bond acceptors	1
Hydrogen bond donors	1
Rotatable bonds	2
Molecular weight (Da)	200.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Structure pdb	7EJA 9CBM 6K42 6K41
Ligand site mutations	α_2A α_2B

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	6.13	6.13	6.13	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.17	8.17	8.17	Drug Central
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	5.53	5.53	5.53	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.19	8.19	8.19	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	7.97	7.97	7.97	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	10.82	10.82	10.82	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	7.60	8.60	9.60	Guide to Pharmacology
α_2A	ADA2A	Rat	Adrenoceptors	A	pKi	8.30	9.98	10.82	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	7.30	7.95	8.60	ChEMBL
α_2A	ADA2A	Rat	Adrenoceptors	A	pKi	7.97	7.97	7.97	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	7.50	8.60	9.70	Guide to Pharmacology
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.01	8.01	8.01	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	7.92	7.92	7.92	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	7.00	8.15	9.30	Guide to Pharmacology
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	7.41	7.46	7.51	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.03	8.03	8.03	Drug Central
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	6.04	6.04	6.04	ChEMBL

Showing 1 to 17 of 17 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Bovine	Adrenoceptors	A	pEC50	6.42	6.42	6.42	ChEMBL
α_1A	ADA1A	Bovine	Adrenoceptors	A	pEC50	8.19	8.19	8.19	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	9.30	9.30	9.30	Guide to Pharmacology
α_2A	ADA2A	Human	Adrenoceptors	A	pEC50	8.53	8.53	8.53	Guide to Pharmacology
α_2A	ADA2A	Human	Adrenoceptors	A	pEC50	8.67	8.94	9.17	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pEC50	8.05	8.05	8.05	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pEC50	9.55	9.55	9.55	Guide to Pharmacology
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	10.90	10.90	10.90	Guide to Pharmacology
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	9.20	9.20	9.20	Guide to Pharmacology
α_2C	ADA2C	Human	Adrenoceptors	A	pEC50	9.60	9.60	9.60	Guide to Pharmacology
α_2C	ADA2C	Human	Adrenoceptors	A	pEC50	9.32	9.32	9.32	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	4.50	4.50	4.50	ChEMBL

Showing 1 to 12 of 12 entries

dexmedetomidine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 12

Phase II 15

Phase III 30

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Structure pdb	7EJA 9CBM 6K42 6K41
Ligand site mutations	α_2A α_2B

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Allergic or hypersensitivity conditions of unspecified type	4A8Z	N05C	0.469	3	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Amyotrophic lateral sclerosis	8B60.0	N05C	0.074	2	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Atrial fibrillation, unspecified	BC81.3Z	N05C	0.411	1	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Cerebral ischaemia, unspecified	8B1Z	N05C	0.042	1	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Cough	MD12	N05C	0.466	1	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Delirium, unspecified or unknown cause	6D70.Z	N05C	0.599	3	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Diseases of the circulatory system, unspecified	BE2Z	N05C	0.590	2	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Essential hypertension, unspecified	BA00.Z	N05C	0.600	2	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Injury or harm arising from surgical or medical care, not elsewhere classified, unspecified	NE8Z	N05C	0.549	2	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Insomnia disorders, unspecified	7A0Z	N05C	0.499	3	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Intracranial injury, unspecified	NA07.Z	N05C	0.504	3	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Nausea or vomiting	MD90	N05C	0.375	3	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Neuropathic pain, unspecified	8E43.0Z	N05C	0.374	1	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Obstructive sleep apnoea	7A41	N05C	0.541	3	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Other specified abnormalities of breathing	MD11.Y	N05C	0.264	3	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Other specified disorders associated with tremor	8A04.Y	N05C	0.259	3	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Pain, unspecified	MG3Z	N05C	0.605	3	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Pre-eclampsia, unspecified	JA24.Z	N05C	0.573	2	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Restlessness	MB24.F	N05C	0.577	4	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Sepsis with septic shock	1G41	N05C	0.587	3	Yes

Showing 1 to 20 of 60 entries

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dexmedetomidine

dexmedetomidine

Chemical Properties

Database connections

Bioactivities

dexmedetomidine

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information