CHEMBL3883955


SMILES O=c1ccc(OCCCN2CCC(c3noc4cc(F)ccc34)CC2)nn1-c1c(F)cccc1F
InChIKey JCSJNNBJTFWLCL-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 7
Hydrogen bond donors 0
Rotatable bonds 7
Molecular weight (Da) 484.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 5.8 5.8 5.8 ChEMBL
H1 HRH1 Guinea pig Histamine A pKi 5.7 5.7 5.7 ChEMBL
H1 HRH1 Human Histamine A pKi 5.7 5.7 5.7 ChEMBL
D2 DRD2 Rat Dopamine A pKi 9.3 9.3 9.3 ChEMBL
α1A ADA1A Human Adrenoceptors A pKi 6.47 6.47 6.47 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 8.23 8.23 8.23 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 9.3 9.3 9.3 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.8 5.8 5.8 ChEMBL
D3 DRD3 Human Dopamine A pKi 7.45 7.45 7.45 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 9.52 9.52 9.52 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.23 8.23 8.23 ChEMBL
D2 DRD2 Human Dopamine A pKi 8.3 8.3 8.3 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database