ArrestinDb

diphenhydramine

Agent/drug
Bioactivity

diphenhydramine

SMILES	CN(C)CCOC(c1ccccc1)c1ccccc1
InChIKey	ZZVUWRFHKOJYTH-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	0
Rotatable bonds	6
Molecular weight (Da)	255.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem PubChem GPCRdb
Ligand site mutations	TAS2R40

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	6.43	6.43	6.43	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.19	8.19	8.19	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	6.15	6.15	6.15	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.21	8.21	8.21	Drug Central
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	6.29	6.29	6.29	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.20	8.20	8.20	Drug Central
H₁	HRH1	Human	Histamine	A	pKi	7.90	7.90	7.90	Guide to Pharmacology
H₁	HRH1	Guinea pig	Histamine	A	pKd	7.93	7.93	7.93	ChEMBL
H₁	HRH1	Human	Histamine	A	pKi	7.70	7.77	7.83	ChEMBL
H₁	HRH1	Human	Histamine	A	pKi	5.00	7.49	8.21	PDSP Ki database
H₁	HRH1	Rat	Histamine	A	pKi	7.77	7.77	7.77	PDSP Ki database
H₁	HRH1	Guinea pig	Histamine	A	pKi	7.86	7.97	8.04	PDSP Ki database
H₁	HRH1	Human	Histamine	A	pKi	8.11	8.11	8.11	Drug Central
H₃	HRH3	Human	Histamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
H₄	HRH4	Human	Histamine	A	pKi	4.37	4.67	4.96	ChEMBL
H₄	HRH4	Human	Histamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
H₄	HRH4	Human	Histamine	A	pKi	8.36	8.36	8.36	Drug Central
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pKi	7.08	7.08	7.08	ChEMBL
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pKi	8.15	8.15	8.15	Drug Central
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pKi	7.00	7.00	7.00	PDSP Ki database

Showing 1 to 20 of 32 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	5.89	5.89	5.89	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	5.95	5.95	5.95	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	6.01	6.01	6.01	ChEMBL
H₁	HRH1	Guinea pig	Histamine	A	pIC50	9.00	9.00	9.00	ChEMBL
H₁	HRH1	Human	Histamine	A	pIC50	4.08	4.98	6.77	ChEMBL
H₁	HRH1	Guinea pig	Histamine	A	pIC50	8.05	8.05	8.05	Drug Central
H₄	HRH4	Human	Histamine	A	pIC50	4.96	4.96	4.96	ChEMBL
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pIC50	6.46	6.46	6.46	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	5.60	6.15	6.70	ChEMBL
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pIC50	5.98	5.98	5.98	ChEMBL
M₃	ACM3	Human	Acetylcholine (muscarinic)	A	pIC50	6.19	6.19	6.19	ChEMBL
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pIC50	6.43	6.43	6.43	ChEMBL
M₅	ACM5	Human	Acetylcholine (muscarinic)	A	pIC50	6.79	6.79	6.79	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	4.80	4.80	4.80	ChEMBL

Showing 1 to 14 of 14 entries

diphenhydramine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 3

Phase III 0

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem PubChem GPCRdb
Ligand site mutations	TAS2R40

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Acute nasopharyngitis	CA00	R06A, D04A	0.605	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic or hypersensitivity conditions of unspecified type	4A8Z	R06A, D04A	0.494	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic rhinitis due to other seasonal allergens	CA08.01	R06A, D04A	0.610	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic rhinitis, unspecified	CA08.0Z	R06A, D04A	0.616	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Atopic eczema, unspecified	EA80.Z	R06A, D04A	0.474	2	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Burns, unspecified	NE2Z	R06A, D04A	0.528	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Chronic rhinitis	CA09.0	R06A, D04A	0.571	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Cough	MD12	R06A, D04A	0.603	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Dizziness and giddiness, unspecified	MB48.Z	R06A, D04A	0.462	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Insomnia disorders, unspecified	7A0Z	R06A, D04A	0.579	2	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Motion sickness	NF08.3	R06A, D04A	0.598	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Nasal congestion	MD11.9	R06A, D04A	0.607	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Nausea	MD90.0	R06A, D04A	0.592	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Nausea or vomiting	MD90	R06A, D04A	0.526	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Oral aphthae or aphtha-like ulceration	DA01.10	R06A, D04A	0.092	2	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Oral mucositis	DA01.11	R06A, D04A	0.259	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Pain, unspecified	MG3Z	R06A, D04A	0.591	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Pruritus, unspecified	EC90.Z	R06A, D04A	0.602	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Sunburn, unspecified	EJ40.Z	R06A, D04A	0.567	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Urticaria of unspecified type	EB05	R06A, D04A	0.606	4	Yes

Showing 1 to 20 of 21 entries

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diphenhydramine

diphenhydramine

Chemical Properties

Database connections

Bioactivities

diphenhydramine

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information