dynorphin A


SMILES None
InChIKey JMNJYGMAUMANNW-FIXZTSJVSA-N
Sequence YGGFLRRIRPKLKWDNQ

Chemical properties

Hydrogen bond acceptors None
Hydrogen bond donors None
Rotatable bonds None
Molecular weight (Da)

Drug properties

Molecular type Peptide
Endogenous/Surrogate Endogenous
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
δ OPRD Human Opioid A pKi 7.4 7.4 7.4 Guide to Pharmacology
κ OPRK Human Opioid A pKi 8.3 9.55 10.8 Guide to Pharmacology
κ OPRK Rat Opioid A pKi 10.0 10.15 10.3 Guide to Pharmacology
δ OPRD Human Opioid A pKi 8.23 8.23 8.23 ChEMBL
μ OPRM Human Opioid A pKi 8.03 8.03 8.03 ChEMBL
δ OPRD Human Opioid A pKi 6.0 6.0 6.0 PDSP Ki database
κ OPRK Human Opioid A pKi 9.3 9.3 9.3 PDSP Ki database
μ OPRM Human Opioid A pKi 7.49 7.49 7.49 PDSP Ki database
κ OPRK Human Opioid A pKi 9.68 9.68 9.68 ChEMBL
μ OPRM Human Opioid A pKi 8.1 8.1 8.1 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
κ OPRK Mouse Opioid A pIC50 9.4 9.4 9.4 Guide to Pharmacology
δ OPRD Mouse Opioid A pIC50 7.4 7.4 7.4 ChEMBL
δ OPRD Human Opioid A pIC50 8.6 8.6 8.6 ChEMBL
δ OPRD Human Opioid A pEC50 7.73 7.73 7.73 ChEMBL
μ OPRM Human Opioid A pEC50 6.67 6.67 6.67 ChEMBL
κ OPRK Human Opioid A pEC50 8.2 8.82 9.39 ChEMBL
κ OPRK Guinea pig Opioid A pIC50 9.64 9.64 9.64 ChEMBL