CHEMBL404000


SMILES NC1CCc2ccc(CCN3CCN(c4nsc5ccccc45)CC3)cc21
InChIKey QLWUWVNGTYIEIX-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 4
Molecular weight (Da) 378.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α1A ADA1A Rat Adrenoceptors A pKi 8.56 8.56 8.56 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 10.05 10.05 10.05 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.7 8.7 8.7 ChEMBL
D2 DRD2 Human Dopamine A pKi 7.68 7.68 7.68 ChEMBL
D2 DRD2 Human Dopamine A pKi 7.68 7.68 7.68 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.7 8.7 8.7 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 10.05 10.05 10.05 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database