ArrestinDb

AMPHETAMINE

Agent/drug
Bioactivity

AMPHETAMINE

SMILES	CC(N)Cc1ccccc1
InChIKey	KWTSXDURSIMDCE-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	1
Hydrogen bond donors	1
Rotatable bonds	2
Molecular weight (Da)	135.1

Database connections

ChEMBL_compound_ids PubChem DrugBank PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.17	5.17	5.17	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	4.89	4.89	4.89	PDSP Ki database
5-HT_2B	5HT2B	Rat	5-Hydroxytryptamine	A	pKd	5.27	5.27	5.27	ChEMBL
5-HT_2B	5HT2B	Rat	5-Hydroxytryptamine	A	pKd	8.28	8.28	8.28	Drug Central
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	4.89	4.89	4.89	PDSP Ki database
TA₁	TAAR1	Rat	Trace amine	A	pKi	6.64	6.64	6.64	PDSP Ki database
TA₁	TAAR1	Mouse	Trace amine	A	pKi	7.05	7.05	7.05	PDSP Ki database

Showing 1 to 7 of 7 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

TA₁	TAAR1	Human	Trace amine	A	pEC50	8.21	8.21	8.21	Drug Central

Showing 1 to 1 of 1 entry

AMPHETAMINE

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 0

Phase II 1

Phase III 0

Phase IV 2

Database connections

ChEMBL_compound_ids PubChem DrugBank PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease

Gene	Protein	Receptor family	Ligand type	Class	Name	Phase	ICD11	ATC	Association score

TAAR1	TA₁ receptor	Trace amine receptors	Aminergic receptors	A	Attention deficit hyperactivity disorder, presentation unspecified	4	6A05.Z		0.026
TAAR1	TA₁ receptor	Trace amine receptors	Aminergic receptors	A	Cocaine dependence, unspecified	2	6C45.2Z		0.007

Showing 1 to 2 of 2 entries