ArrestinDb

FITM

Agent/drug
Bioactivity

FITM

SMILES	CC(C)Nc1cc(-c2csc(N(C)C(=O)c3ccc(F)cc3)n2)ncn1
InChIKey	WIVGIKIKQHUFOD-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	6
Hydrogen bond donors	1
Rotatable bonds	5
Molecular weight (Da)	371.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Structure pdb	4OR2
Ligand site mutations	mGlu₁

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

mGlu₁	GRM1	Rat	Metabotropic glutamate	C	pKi	8.27	8.27	8.27	Guide to Pharmacology
mGlu₁	GRM1	Rat	Metabotropic glutamate	C	pKi	8.27	8.27	8.27	ChEMBL

Showing 1 to 2 of 2 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

mGlu₁	GRM1	Human	Metabotropic glutamate	C	pIC50	8.29	8.29	8.29	ChEMBL
mGlu₁	GRM1	Rat	Metabotropic glutamate	C	pIC50	7.86	7.86	7.86	ChEMBL
mGlu₅	GRM5	Human	Metabotropic glutamate	C	pIC50	5.16	5.16	5.16	ChEMBL

Showing 1 to 3 of 3 entries

FITM

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Structure pdb	4OR2
Ligand site mutations	mGlu₁

Compound is not listed as a drug.