CHEMBL44246


SMILES N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1
InChIKey KUWBXRGRMQZCSS-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 6
Rotatable bonds 11
Molecular weight (Da) 473.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
Y1 NPY1R Human Neuropeptide Y A pKi 8.34 8.34 8.34 ChEMBL
PrRP PRLHR Human Prolactin-releasing peptide A pKi 5.0 5.0 5.0 PDSP Ki database
Y5 NPY5R Human Neuropeptide Y A pKi 6.0 6.0 6.0 PDSP Ki database
Y5 NPY5R Rat Neuropeptide Y A pKi 6.0 6.0 6.0 PDSP Ki database
Y1 NPY1R Rat Neuropeptide Y A pKi 8.49 8.49 8.49 PDSP Ki database
Y2 NPY2R Chicken Neuropeptide Y A pKi 6.0 6.0 6.0 PDSP Ki database
Y2 NPY2R Guinea pig Neuropeptide Y A pKi 5.0 5.0 5.0 PDSP Ki database
Y1 NPY1R Human Neuropeptide Y A pKi 8.01 8.01 8.01 PDSP Ki database
Y1 Q9GK75 Rhesus macaque Neuropeptide Y A pKi 8.16 8.16 8.16 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
Y5 NPY5R Human Neuropeptide Y A pIC50 4.1 4.1 4.1 ChEMBL
Y1 NPY1R Human Neuropeptide Y A pIC50 7.77 8.0 8.23 ChEMBL