CHEMBL427518


SMILES COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1
InChIKey FJGYVPIKFQWJJI-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 9
Molecular weight (Da) 419.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 7.0 7.0 7.0 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 7.43 7.43 7.43 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.57 6.57 6.57 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pIC50 7.43 7.43 7.43 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pIC50 5.01 5.01 5.01 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 5.29 5.29 5.29 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pIC50 6.57 6.57 6.57 ChEMBL