CHEMBL488248


SMILES Cn1c(-c2ccc(OCCCN3CCCC3)cc2)nc2ccccc2c1=O
InChIKey PRPSMPHMELIHFQ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 0
Rotatable bonds 6
Molecular weight (Da) 363.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H3 HRH3 Mouse Histamine A pKd 8.51 8.55 8.59 ChEMBL
H3 HRH3 Mouse Histamine A pKi 8.62 8.62 8.62 ChEMBL
H3 HRH3 Rat Histamine A pKi 7.92 7.92 7.92 ChEMBL
H3 HRH3 Human Histamine A pKi 8.38 9.02 9.66 ChEMBL
H3 HRH3 Human Histamine A pKi 8.38 8.38 8.38 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H3 HRH3 Mouse Histamine A pEC50 8.02 8.02 8.02 ChEMBL
α1A ADA1A Human Adrenoceptors A pIC50 5.66 5.66 5.66 ChEMBL
H3 HRH3 Human Histamine A pIC50 9.17 9.17 9.17 ChEMBL