CHEMBL497963


SMILES Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1
InChIKey UZLFJOXUSYBNKZ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 8
Molecular weight (Da) 453.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pKi 6.3 6.3 6.3 ChEMBL
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 5.6 5.6 5.6 ChEMBL
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 5.9 5.9 5.9 ChEMBL
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 8.7 8.7 8.7 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 9.3 9.3 9.3 ChEMBL
α1B ADA1B Human Adrenoceptors A pKi 6.7 6.7 6.7 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 7.7 7.7 7.7 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 5.7 5.7 5.7 ChEMBL
β2 ADRB2 Human Adrenoceptors A pKi 6.3 6.3 6.3 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 5.6 5.6 5.6 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.6 8.6 8.6 ChEMBL
D2 DRD2 Human Dopamine A pKi 7.2 7.2 7.2 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database