idazoxan


SMILES C1CN=C(N1)C2COC3=CC=CC=C3O2
InChIKey HPMRFMKYPGXPEP-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 1
Molecular weight (Da) 204.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations α2A

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α2B ADA2B Human Adrenoceptors A pKi 7.0 7.43 7.64 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 7.72 7.74 7.75 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 8.1 8.13 8.15 ChEMBL
5-HT2C K7GSR7 Pig 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
α2A ADA2A Human Adrenoceptors A pKi 8.01 8.28 8.72 PDSP Ki database
α2B ADA2B Rat Adrenoceptors A pKi 8.33 8.33 8.33 PDSP Ki database
α2B ADA2B Human Adrenoceptors A pKi 7.0 7.21 7.43 PDSP Ki database
α2A ADA2A Human Adrenoceptors A pKi 7.2 7.2 7.2 Guide to Pharmacology
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.18 6.18 6.18 PDSP Ki database
α2B ADA2B Human Adrenoceptors A pKi 6.4 6.4 6.4 Guide to Pharmacology
α2C ADA2C Human Adrenoceptors A pKi 7.7 8.22 9.25 PDSP Ki database
α2C ADA2C Human Adrenoceptors A pKi 7.2 7.2 7.2 Guide to Pharmacology
D1 DRD1 Human Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 6.79 6.81 6.84 PDSP Ki database
α2C ADA2C North American opossum Adrenoceptors A pKi 8.62 8.62 8.62 PDSP Ki database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
α2A ADA2A Bovine Adrenoceptors A pKi 8.82 8.82 8.82 ChEMBL
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 6.0 6.0 6.0 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
α1A ADA1A Bovine Adrenoceptors A pKi 6.3 6.3 6.3 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α2B ADA2B Human Adrenoceptors A pIC50 7.71 7.71 7.71 ChEMBL
α2C ADA2C Human Adrenoceptors A pIC50 7.27 7.27 7.27 ChEMBL
α2A ADA2A Human Adrenoceptors A pIC50 8.08 8.08 8.08 ChEMBL
α1A ADA1A Human Adrenoceptors A pIC50 5.54 5.54 5.54 ChEMBL
NPS NPSR1 Human Neuropeptide S A Potency 5.0 5.0 5.0 ChEMBL