ArrestinDb

TRIFLUPROMAZINE

Agent/drug
Bioactivity

TRIFLUPROMAZINE

SMILES	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21
InChIKey	XSCGXQMFQXDFCW-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	0
Rotatable bonds	4
Molecular weight (Da)	352.1

Database connections

ChEMBL_compound_ids ChEMBL_compound_ids PubChem PubChem DrugBank PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.40	8.40	8.40	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.08	8.08	8.08	Drug Central
D₁	DRD1	Bovine	Dopamine	A	pKi	6.28	6.28	6.28	PDSP Ki database
D₂	DRD2	Human	Dopamine	A	pKi	8.55	8.55	8.55	PDSP Ki database
D₂	DRD2	Bovine	Dopamine	A	pKi	8.68	8.68	8.68	PDSP Ki database
D₂	DRD2	Human	Dopamine	A	pKi	8.07	8.07	8.07	Drug Central
H₁	HRH1	Rat	Histamine	A	pKi	7.28	7.28	7.28	PDSP Ki database

Showing 1 to 7 of 7 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	6.00	6.40	6.80	ChEMBL
NPS	NPSR1	Human	Neuropeptide S	A	Potency	4.90	4.90	4.90	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	4.40	4.40	4.40	ChEMBL

Showing 1 to 3 of 3 entries

TRIFLUPROMAZINE

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV 5

Database connections

ChEMBL_compound_ids ChEMBL_compound_ids PubChem PubChem DrugBank PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease

Gene	Protein	Receptor family	Ligand type	Class	Name	Phase	ICD11	ATC	Association score

5HT2B	5-HT_2B receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Schizophrenia or other primary psychotic disorders, unspecified	4	6A2Z		0.463
ACM1	M₁ receptor	Acetylcholine receptors (muscarinic)	Aminergic receptors	A	Schizophrenia or other primary psychotic disorders, unspecified	4	6A2Z		0.002
ACM2	M₂ receptor	Acetylcholine receptors (muscarinic)	Aminergic receptors	A	Schizophrenia or other primary psychotic disorders, unspecified	4	6A2Z		0.005
DRD1	D₁ receptor	Dopamine receptors	Aminergic receptors	A	Schizophrenia or other primary psychotic disorders, unspecified	4	6A2Z		0.374
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	A	Schizophrenia or other primary psychotic disorders, unspecified	4	6A2Z		0.615

Showing 1 to 5 of 5 entries