N-α-methylhistamine


SMILES CNCCc1cnc[nH]1
InChIKey PHSPJQZRQAJPPF-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 3
Molecular weight (Da) 125.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations H3

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H3 HRH3 Mouse Histamine A pKi 7.72 7.72 7.72 ChEMBL
H3 HRH3 Human Histamine A pKi 8.4 8.4 8.4 PDSP Ki database
H3 HRH3 Human Histamine A pKi 8.4 8.4 8.4 ChEMBL
H4 HRH4 Human Histamine A pKi 6.5 6.5 6.5 PDSP Ki database
H4 HRH4 Human Histamine A pKi 6.5 6.5 6.5 ChEMBL
H4 HRH4 Human Histamine A pKi 6.8 7.0 7.2 Guide to Pharmacology
H3 HRH3 Rat Histamine A pKi 7.82 8.86 9.35 PDSP Ki database
H3 HRH3 Mouse Histamine A pKd 9.0 9.0 9.0 Guide to Pharmacology
H3 HRH3 Mouse Histamine A pKi 9.0 9.0 9.0 Guide to Pharmacology
H3 HRH3 Guinea pig Histamine A pKi 8.6 8.6 8.6 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H3 HRH3 Human Histamine A pEC50 9.4 9.4 9.4 ChEMBL
H4 HRH4 Human Histamine A pEC50 6.1 6.1 6.1 ChEMBL