ArrestinDb

TIAPRIDE

Agent/drug
Bioactivity

TIAPRIDE

SMILES	CCN(CC)CCNC(=O)c1cc(S(C)(=O)=O)ccc1OC
InChIKey	JTVPZMFULRWINT-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	5
Hydrogen bond donors	1
Rotatable bonds	8
Molecular weight (Da)	328.1

Database connections

ChEMBL_compound_ids PubChem DrugBank PubChem GPCRdb
Ligand site mutations	D₂ D₄

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.11	6.11	6.11	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.21	8.21	8.21	Drug Central
D₂	DRD2	Human	Dopamine	A	pKi	6.39	6.39	6.39	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pKi	7.11	7.11	7.11	PDSP Ki database
D₂	DRD2	Human	Dopamine	A	pKi	6.65	7.08	7.51	PDSP Ki database
D₂	DRD2	Human	Dopamine	A	pKi	8.15	8.15	8.15	Drug Central
D₃	DRD3	Human	Dopamine	A	pKi	6.41	6.41	6.41	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	6.49	6.75	7.02	PDSP Ki database
D₃	DRD3	Human	Dopamine	A	pKi	8.17	8.17	8.17	Drug Central
D₄	DRD4	Human	Dopamine	A	pKi	7.85	7.85	7.85	PDSP Ki database
D₄	DRD4	Human	Dopamine	A	pKi	8.10	8.10	8.10	Drug Central

Showing 1 to 11 of 11 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	5.68	5.68	5.68	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	5.91	5.91	5.91	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	5.94	5.94	5.94	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	5.00	5.72	6.45	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	5.20	5.20	5.20	ChEMBL

Showing 1 to 5 of 5 entries

TIAPRIDE

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved Yes

Database connections

ChEMBL_compound_ids PubChem DrugBank PubChem GPCRdb
Ligand site mutations	D₂ D₄

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Alcohol dependence, unspecified	6C40.2Z		0.456	4	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Huntington disease	8A01.10		0.015	4	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Movement disorders, unspecified	8A0Z		0.474	4	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Restlessness	MB24.F		0.575	4	Yes
5HT1B	5-HT_1B receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Alcohol dependence, unspecified	6C40.2Z		0.020	4	Yes
5HT1B	5-HT_1B receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Huntington disease	8A01.10		0.016	4	Yes
5HT1B	5-HT_1B receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Movement disorders, unspecified	8A0Z		0.370	4	Yes
5HT1D	5-HT_1D receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Alcohol dependence, unspecified	6C40.2Z		0.004	4	Yes
5HT1D	5-HT_1D receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Huntington disease	8A01.10		0.002	4	Yes
5HT1D	5-HT_1D receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Movement disorders, unspecified	8A0Z		0.370	4	Yes
5HT1E	5-HT_1E receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Movement disorders, unspecified	8A0Z		0.370	4	Yes
5HT1F	5-HT_1F receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Movement disorders, unspecified	8A0Z		0.370	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Alcohol dependence, unspecified	6C40.2Z		0.268	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Huntington disease	8A01.10		0.275	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Movement disorders, unspecified	8A0Z		0.530	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Restlessness	MB24.F		0.602	4	Yes
5HT2B	5-HT_2B receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Movement disorders, unspecified	8A0Z		0.370	4	Yes
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Alcohol dependence, unspecified	6C40.2Z		0.389	4	Yes
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Huntington disease	8A01.10		0.272	4	Yes
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Movement disorders, unspecified	8A0Z		0.528	4	Yes

Showing 1 to 20 of 46 entries

Join us

Cite us

Main reference

TIAPRIDE

TIAPRIDE

Chemical Properties

Database connections

Bioactivities

TIAPRIDE

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information