ArrestinDb

ORPHENADRINE

Agent/drug
Bioactivity

ORPHENADRINE

SMILES	Cc1ccccc1C(OCCN(C)C)c1ccccc1
InChIKey	QVYRGXJJSLMXQH-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	0
Rotatable bonds	6
Molecular weight (Da)	269.2

Database connections

ChEMBL_compound_ids ChEMBL_compound_ids PubChem DrugBank PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.09	6.09	6.09	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.22	8.22	8.22	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.06	6.06	6.06	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.22	8.22	8.22	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	6.90	6.90	6.90	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.16	8.16	8.16	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	5.67	5.67	5.67	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.25	8.25	8.25	Drug Central
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	6.55	6.55	6.55	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.18	8.18	8.18	Drug Central
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	6.28	6.28	6.28	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	8.20	8.20	8.20	Drug Central
H₁	HRH1	Human	Histamine	A	pKi	6.84	6.84	6.84	ChEMBL
H₁	HRH1	Human	Histamine	A	pKi	8.10	8.10	8.10	Drug Central
H₂	HRH2	Human	Histamine	A	pKi	5.17	5.17	5.17	ChEMBL
H₂	HRH2	Human	Histamine	A	pKi	8.29	8.29	8.29	Drug Central
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pKi	7.44	7.44	7.44	ChEMBL
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pKi	7.32	7.32	7.32	PDSP Ki database
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pKi	8.13	8.13	8.13	Drug Central
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	pKi	7.39	7.39	7.39	PDSP Ki database

Showing 1 to 20 of 35 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	5.67	5.67	5.67	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	5.72	5.72	5.72	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	6.36	6.36	6.36	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	5.47	5.47	5.47	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	6.27	6.27	6.27	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pIC50	5.95	5.95	5.95	ChEMBL
H₁	HRH1	Rat	Histamine	A	pIC50	6.79	6.79	6.79	ChEMBL
H₁	HRH1	Human	Histamine	A	pIC50	4.01	4.96	5.91	ChEMBL
H₁	HRH1	Rat	Histamine	A	pIC50	8.17	8.17	8.17	Drug Central
H₂	HRH2	Human	Histamine	A	pIC50	5.16	5.16	5.16	ChEMBL
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pIC50	6.83	6.83	6.83	ChEMBL
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pIC50	6.42	6.42	6.42	ChEMBL
M₃	ACM3	Human	Acetylcholine (muscarinic)	A	pIC50	6.76	6.76	6.76	ChEMBL
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pIC50	6.90	6.90	6.90	ChEMBL
M₅	ACM5	Human	Acetylcholine (muscarinic)	A	pIC50	7.55	7.55	7.55	ChEMBL
NPS	NPSR1	Human	Neuropeptide S	A	Potency	7.70	7.70	7.70	ChEMBL

Showing 1 to 16 of 16 entries

ORPHENADRINE

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 1

Approved Yes

Database connections

ChEMBL_compound_ids ChEMBL_compound_ids PubChem DrugBank PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Low back pain, unspecified	ME84.2Z		0.491	3	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Pain, unspecified	MG3Z		0.591	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Parkinson disease, unspecified	8A00.0Z		0.462	4	Yes

Showing 1 to 3 of 3 entries