JNJ-16567083
SMILES | CO[C@@H]1CC[C@@H](CC1)C(=O)c1ccc2c(c1)cc(c(n2)C)CC |
InChIKey | VEURHZYLLRSEGL-RHNCMZPLSA-N |
Chemical properties
Hydrogen bond acceptors | 3 |
Hydrogen bond donors | 0 |
Rotatable bonds | 4 |
Molecular weight (Da) | 311.2 |
Drug properties
Molecular type | Small molecule |
Physiological/Surrogate | Surrogate |
Approved drug | No |
Database connections
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
mGlu1 | GRM1 | Rat | Metabotropic glutamate | C | pKi | 9.06 | 9.06 | 9.06 | ChEMBL |
mGlu5 | GRM5 | Rat | Metabotropic glutamate | C | pKi | 5.63 | 5.63 | 5.63 | ChEMBL |
mGlu1 | GRM1 | Human | Metabotropic glutamate | C | pKi | 9.06 | 9.06 | 9.06 | ChEMBL |
mGlu1 | GRM1 | Rat | Metabotropic glutamate | C | pKi | 8.85 | 8.85 | 8.85 | Guide to Pharmacology |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
mGlu1 | GRM1 | Rat | Metabotropic glutamate | C | pIC50 | 8.52 | 8.52 | 8.52 | ChEMBL |