JNJ-5207852
SMILES | C1CCN(CC1)CCCOc1ccc(cc1)CN1CCCCC1 |
InChIKey | PTKHFRNHJULJKT-UHFFFAOYSA-N |
Chemical properties
Hydrogen bond acceptors | 3 |
Hydrogen bond donors | 0 |
Rotatable bonds | 7 |
Molecular weight (Da) | 316.3 |
Drug properties
Molecular type | Small molecule |
Endogenous/Surrogate | Surrogate |
Approved drug | No |
Database connections
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
H3 | HRH3 | Human | Histamine | A | pKi | 9.2 | 9.2 | 9.2 | Guide to Pharmacology |
H3 | HRH3 | Rat | Histamine | A | pKi | 8.9 | 9.1 | 9.34 | ChEMBL |
H3 | HRH3 | Human | Histamine | A | pKi | 8.03 | 9.23 | 10.22 | ChEMBL |
H3 | HRH3 | Human | Histamine | A | pKd | 9.08 | 9.69 | 9.84 | ChEMBL |
H3 | HRH3 | Human | Histamine | A | pKi | 9.22 | 9.22 | 9.22 | PDSP Ki database |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
H3 | HRH3 | Human | Histamine | A | pIC50 | 9.28 | 9.28 | 9.28 | ChEMBL |