MK 678


SMILES CC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1C)CC2=CC=CC=C2)C(C)C)CCCCN)CC3=CNC4=CC=CC=C43)CC5=CC=C(C=C5)O.CC(=O)O
InChIKey FIKSSPSBVSPVFU-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 9
Hydrogen bond donors 9
Rotatable bonds 11
Molecular weight (Da) 868.4

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
SST4 SSR4 Human Somatostatin A pKi 5.31 6.5 8.19 PDSP Ki database
SST5 SSR5 Human Somatostatin A pKi 6.0 7.71 8.7 PDSP Ki database
SST1 SSR1 Human Somatostatin A pKi 5.0 5.8 6.0 PDSP Ki database
SST3 SSR3 Mouse Somatostatin A pKi 6.57 7.47 7.92 PDSP Ki database
SST2 SSR2 Mouse Somatostatin A pKi 7.06 9.32 10.15 PDSP Ki database
SST4 SSR4 Rat Somatostatin A pKi 8.14 8.2 8.26 PDSP Ki database
SST2 SSR2 Human Somatostatin A pKi 8.82 9.84 10.3 PDSP Ki database
SST3 SSR3 Human Somatostatin A pKi 6.57 7.25 7.7 PDSP Ki database
SST4 SSR4 Mouse Somatostatin A pKi 6.0 6.0 6.0 PDSP Ki database
SST2 SSR2 Rat Somatostatin A pKi 9.32 9.32 9.32 PDSP Ki database
SST3 SSR3 Rat Somatostatin A pKi 7.35 7.35 7.35 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database