SB-277011-A


SMILES C1CC(CCC1CCN2CCC3=C(C2)C=CC(=C3)C#N)NC(=O)C4=CC=NC5=CC=CC=C45
InChIKey OLWRVVHPJFLNPW-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 5
Molecular weight (Da) 438.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.3 5.3 5.3 PDSP Ki database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 5.2 5.2 5.2 PDSP Ki database
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 5.79 5.79 5.79 PDSP Ki database
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pKi 5.2 5.2 5.2 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 5.89 5.89 5.89 PDSP Ki database
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 5.98 5.98 5.98 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 7.95 7.95 7.95 PDSP Ki database
D3 DRD3 Rat Dopamine A pKi 7.97 7.97 7.97 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 5.55 5.55 5.55 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database