Niguldipine(+)


SMILES CC1=C(C(C(=C(N1)C)C(=O)OCCCN2CCC(CC2)(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-])C(=O)OC
InChIKey SVJMLYUFVDMUHP-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 8
Hydrogen bond donors 1
Rotatable bonds 10
Molecular weight (Da) 609.3

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α1B A0A4X1U0M4 Pig Adrenoceptors A pKi 6.5 6.5 6.5 PDSP Ki database
α1A Q9TSW7 Pig Adrenoceptors A pKi 5.6 6.9 7.7 PDSP Ki database
α1B ADA1B Human Adrenoceptors A pKi 6.35 6.35 6.35 PDSP Ki database
α1D ADA1D Human Adrenoceptors A pKi 6.29 7.3 8.32 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database