Naltrexone


SMILES C1CC1CN2CCC34C5C(=O)CCC3(C2CC6=C4C(=C(C=C6)O)O5)O
InChIKey DQCKKXVULJGBQN-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 2
Molecular weight (Da) 341.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
μ OPRM Rat Opioid A pKi 9.3 9.56 10.08 PDSP Ki database
μ OPRM Human Opioid A pKi 8.44 9.38 9.96 PDSP Ki database
δ OPRD Rat Opioid A pKi 8.1 8.1 8.1 PDSP Ki database
κ OPRK Rat Opioid A pKi 9.29 9.29 9.29 PDSP Ki database
κ OPRK Human Opioid A pKi 8.28 9.08 10.38 PDSP Ki database
δ OPRD Human Opioid A pKi 6.93 7.53 7.97 PDSP Ki database
NOP OPRX Human Opioid A pKi 5.0 5.0 5.0 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database