ArrestinDb

ketotifen

Agent/drug
Bioactivity

ketotifen

SMILES	CN1CCC(=C2c3ccccc3CC(=O)c3sccc32)CC1
InChIKey	ZCVMWBYGMWKGHF-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	0
Rotatable bonds	0
Molecular weight (Da)	309.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	H₁

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.24	8.24	8.24	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	5.74	5.74	5.74	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.96	6.03	6.09	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.22	8.22	8.22	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.22	6.36	6.49	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.19	8.19	8.19	Drug Central
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.84	5.84	5.84	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.23	8.23	8.23	Drug Central
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	5.76	5.76	5.76	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	7.36	7.74	8.05	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.09	8.09	8.09	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	7.50	7.52	7.54	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.12	8.12	8.12	Drug Central
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	6.70	6.83	7.08	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.15	8.15	8.15	Drug Central
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	6.08	6.18	6.28	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	8.20	8.20	8.20	Drug Central
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	6.39	6.39	6.39	ChEMBL
D₁	DRD1	Human	Dopamine	A	pKi	6.36	6.44	6.52	ChEMBL
D₁	DRD1	Human	Dopamine	A	pKi	8.20	8.20	8.20	Drug Central

Showing 1 to 20 of 44 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	5.43	5.43	5.43	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	5.66	5.66	5.66	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	6.15	6.15	6.15	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	5.60	5.60	5.60	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	8.25	8.25	8.25	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	7.51	7.51	7.51	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	7.34	7.34	7.34	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	6.80	6.80	6.80	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pIC50	5.94	5.94	5.94	ChEMBL
D₁	DRD1	Human	Dopamine	A	pIC50	6.06	6.06	6.06	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	5.71	5.71	5.71	ChEMBL
H₁	HRH1	Human	Histamine	A	pIC50	5.64	7.64	9.00	ChEMBL
H₂	HRH2	Human	Histamine	A	pIC50	5.38	5.38	5.38	ChEMBL
H₄	HRH4	Human	Histamine	A	pIC50	4.68	4.68	4.68	ChEMBL
H₄	HRH4	Human	Histamine	A	pIC50	8.33	8.33	8.33	Drug Central
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	6.00	6.38	6.75	ChEMBL
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pIC50	5.95	5.95	5.95	ChEMBL
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pIC50	6.08	6.08	6.08	ChEMBL
M₃	ACM3	Human	Acetylcholine (muscarinic)	A	pIC50	5.66	5.66	5.66	ChEMBL
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pIC50	6.00	6.00	6.00	ChEMBL

Showing 1 to 20 of 23 entries

ketotifen

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 1

Phase III 5

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	H₁

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic conjunctivitis	9A60.02	R06A, S01G	0.589	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic or hypersensitivity conditions of unspecified type	4A8Z	R06A, S01G	0.494	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Atopic eczema, unspecified	EA80.Z	R06A, S01G	0.474	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	COVID-19	RA01	R06A, S01G	0.486	3	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Chronic pain, unspecified	MG30.Z	R06A, S01G	0.323	3	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Chronic widespread pain	MG30.01	R06A, S01G	0.259	3	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Dyspepsia	MD92	R06A, S01G	0.259	3	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Flexion deformity	FA31.2	R06A, S01G	0.074	2	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Fracture of unspecified body region	ND56.2	R06A, S01G	0.324	3	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Other allergic rhinitis	CA08.03	R06A, S01G	0.602	4	Yes

Showing 1 to 10 of 10 entries