KMN-159


SMILES FC1(C(N([C@H](C1)/C=C/[C@H]([C@H](CC#CCC)C)O)CCCCCCC(=O)O)=O)F
InChIKey ZSUOOBFOIDLLEI-GPVXIOJZSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 11
Molecular weight (Da) 399.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
EP2 PE2R2 Human Prostanoid A pKi 5.3 5.3 5.3 ChEMBL
EP3 PE2R3 Human Prostanoid A pKi 6.59 6.59 6.59 ChEMBL
EP4 PE2R4 Human Prostanoid A pKi 9.31 9.37 9.42 ChEMBL
EP4 PE2R4 Human Prostanoid A pKi 9.42 9.42 9.42 Guide to Pharmacology
EP4 PE2R4 Rat Prostanoid A pKi 9.62 9.62 9.62 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
EP2 PE2R2 Human Prostanoid A pEC50 5.13 5.13 5.13 ChEMBL
EP4 PE2R4 Human Prostanoid A pEC50 8.58 9.67 10.42 ChEMBL
EP4 PE2R4 Human Prostanoid A pIC50 8.89 8.89 8.89 ChEMBL